Fabrication of Medical Cannula for advanced extracorporeal life support devices.

制造用于先进体外生命支持设备的医用插管。

• 批准号: 566795-2021
• 负责人: Dalton, Colin
• 金额: $ 4.95万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=722356
• 关键词: Fabrication; Medical; Cannula; advanced; extracorporeal

Extracorporeal membrane oxygenation (ECMO), also known as extracorporeal life support (ECLS), is a technique of providing prolonged cardiac and respiratory support to persons whose heart and lungs are unable to sustain life. ECMO systems oxygenate the blood, taking over operation of the lungs and heart, allowing the organs to rest and recuperate, or while waiting for organ transplant. Current ECMO systems are bulky and complex for use in the field and are situated in hospitals ICUs (Intensive Care Units). Due to their proven lifesaving abilities, there is a strong move toward having ECMO units in ambulances. Canadian company Elsius Biomedical Corp. is developing a portable ECMO system to address this need. A crucial component of ECMO systems are the cannula, or tubes, that connect the system to the patient, enabling removal of the blood and reintroducing it back into the patient after reoxygenation. These cannulae have specific requirements to enable the ECMO process to work, such as pliability after insertion, kink resistance, long term biocompatibility, placement markers, dual lumen and flow control, to name a few, and are difficult to manufacture. Elsius is continuing a partnership with the Dalton Group to investigate, design, evaluate and develop a reliable and automated process for cannulae microfabrication which will allow Elsius to finalize their ECMO production cycle. This project will address technical challenges in the complex microfabrication process to create cannulae, by identifying and controlling key process variables such as cannulae geometry, coating temperature and dipping time, to ensure uniform layering. Once optimized, the process will be automated to create a repeatable and reliable manufacturing process. There are currently no cannulae manufacturers in Canada. As cannulae can be used in other medical situations, like cardiac surgery and neurosurgery, this engineering solution will result in many benefits to the Canadian Healthcare system.

体外膜氧合（ECMO），也称为体外生命支持（ECLS），是一种为心肺不能维持生命的人提供长时间心脏和呼吸支持的技术。ECMO系统为血液充氧，接管肺和心脏的运作，让器官休息和恢复，或等待器官移植。目前的ECMO系统体积庞大，复杂，无法在现场使用，并且位于医院的icu（重症监护病房）。由于它们被证明具有挽救生命的能力，在救护车上有一个强有力的举动。加拿大Elsius Biomedical公司正在开发一种便携式ECMO系统来满足这一需求。ECMO系统的一个关键组成部分是连接系统和患者的导管，它可以将血液抽出，并在再氧合后将其重新引入患者体内。这些套管具有特定的要求，使ECMO过程能够工作，例如插入后的柔韧性，抗扭结性，长期生物相容性，放置标记，双腔和流量控制，仅举几例，并且难以制造。Elsius正在继续与道尔顿集团合作，调查、设计、评估和开发一种可靠的自动化套管微加工工艺，这将使Elsius能够完成ECMO的生产周期。该项目将通过识别和控制关键工艺变量（如套管几何形状、涂层温度和浸渍时间）来解决复杂微加工过程中制造套管的技术挑战，以确保均匀分层。一旦优化，该过程将自动化，以创建可重复和可靠的制造过程。目前加拿大没有套管制造商。由于套管可以用于其他医疗情况，如心脏手术和神经外科，这种工程解决方案将为加拿大医疗保健系统带来许多好处。