Engineering multifunctional hierarchical surface microstructures for bacterial sensing and biofilm prevention
用于细菌传感和生物膜预防的多功能分层表面微结构工程
基本信息
- 批准号:435940-2013
- 负责人:
- 金额:$ 1.97万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2017
- 资助国家:加拿大
- 起止时间:2017-01-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Natural surfaces, such as plant leaves, and intestinal walls, feature complex microstructures which can respond to their environment, chemically and physically. For example, plants can open and close pores (stomata), and cells can sense chemical stimuli, and move microhairs (cilia) to cause diffusion, move mucus layers, and prevent bacterial adhesion. This proposal is directed towards the design and engineering of responsive microstructured surfaces that can be used to sense chemical species, and physically move arrays of microhairs, or pores, which are based on these biological examples. The active motion of the microhairs can be used to control surface diffusion of chemical species, or the adhesion of particles, or prevent the attachment of bacterial cells. The opening and closing of surface pores can be used to control drug release, or particle capture. Another important design element is the control of optically-tunable metal nanoparticles, which effect the sensitivity of certain quantitative chemical measurements (known as Raman spectroscopy). These moving surface structures will be designed to tune this sensing sensitivity, which could ultimately be very useful for the identification of bacterial strains. In this way, we are designing adaptive, complex surface microstructures that can respond to their environment using biological inspirations.
自然表面,如植物叶片和肠壁,具有复杂的微观结构,可以对其环境做出化学和物理反应。例如,植物可以打开和关闭气孔(气孔),细胞可以感知化学刺激,并移动微毛(纤毛)以引起扩散,移动粘液层并防止细菌粘附。该建议是针对设计和工程的响应微结构化的表面,可用于感测化学物种,并物理移动阵列的微毛,或孔,这是基于这些生物学的例子。微毛的主动运动可用于控制化学物质的表面扩散、颗粒的粘附或防止细菌细胞的附着。表面孔的打开和关闭可用于控制药物释放或颗粒捕获。另一个重要的设计元素是光学可调金属纳米颗粒的控制,其影响某些定量化学测量(称为拉曼光谱)的灵敏度。这些移动的表面结构将被设计成调整这种传感灵敏度,这最终可能对细菌菌株的识别非常有用。通过这种方式,我们正在设计自适应的复杂表面微结构,这些微结构可以使用生物灵感对其环境做出反应。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Hatton, Benjamin其他文献
Assembly of large-area, highly ordered, crack-free inverse opal films
- DOI:
10.1073/pnas.1000954107 - 发表时间:
2010-06-08 - 期刊:
- 影响因子:11.1
- 作者:
Hatton, Benjamin;Mishchenko, Lidiya;Aizenberg, Joanna - 通讯作者:
Aizenberg, Joanna
Shape-programmable fluid bubbles for responsive building skins
- DOI:
10.1016/j.jobe.2021.103942 - 发表时间:
2022-01-05 - 期刊:
- 影响因子:6.4
- 作者:
Kay, Raphael;Nitiema, Kevin;Hatton, Benjamin - 通讯作者:
Hatton, Benjamin
Patterning Hierarchy in Direct and Inverse Opal Crystals
- DOI:
10.1002/smll.201102691 - 发表时间:
2012-06-25 - 期刊:
- 影响因子:13.3
- 作者:
Mishchenko, Lidiya;Hatton, Benjamin;Aizenberg, Joanna - 通讯作者:
Aizenberg, Joanna
Design of Ice-free Nanostructured Surfaces Based on Repulsion of Impacting Water Droplets
- DOI:
10.1021/nn102557p - 发表时间:
2010-12-01 - 期刊:
- 影响因子:17.1
- 作者:
Mishchenko, Lidiya;Hatton, Benjamin;Aizenberg, Joanna - 通讯作者:
Aizenberg, Joanna
Low-temperature synthesis of nanoscale silica multilayers - atomic layer deposition in a test tube
- DOI:
10.1039/c0jm00696c - 发表时间:
2010-01-01 - 期刊:
- 影响因子:0
- 作者:
Hatton, Benjamin;Kitaev, Vladimir;Aizenberg, Joanna - 通讯作者:
Aizenberg, Joanna
Hatton, Benjamin的其他文献
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{{ truncateString('Hatton, Benjamin', 18)}}的其他基金
Smart Robotic Surfaces - Multi-scale Actuation of Topographies for Adaptive Adhesion
智能机器人表面 - 地形的多尺度驱动以实现自适应粘附
- 批准号:
RGPIN-2019-06760 - 财政年份:2022
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Smart Robotic Surfaces - Multi-scale Actuation of Topographies for Adaptive Adhesion
智能机器人表面 - 地形的多尺度驱动以实现自适应粘附
- 批准号:
RGPIN-2019-06760 - 财政年份:2021
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Smart Robotic Surfaces - Multi-scale Actuation of Topographies for Adaptive Adhesion
智能机器人表面 - 地形的多尺度驱动以实现自适应粘附
- 批准号:
RGPIN-2019-06760 - 财政年份:2020
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Smart Robotic Surfaces - Multi-scale Actuation of Topographies for Adaptive Adhesion
智能机器人表面 - 地形的多尺度驱动以实现自适应粘附
- 批准号:
RGPIN-2019-06760 - 财政年份:2019
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Engineering multifunctional hierarchical surface microstructures for bacterial sensing and biofilm prevention
用于细菌传感和生物膜预防的多功能分层表面微结构工程
- 批准号:
435940-2013 - 财政年份:2018
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Surface treatments for drains to significantly reduce pathogen biofilms in hospitals**
排水管表面处理可显着减少医院的病原体生物膜**
- 批准号:
534090-2018 - 财政年份:2018
- 资助金额:
$ 1.97万 - 项目类别:
Engage Grants Program
Ultralow adhesion silicone coatings to reduce rates of biofilm formation and associated infection
超低附着力有机硅涂层可降低生物膜形成率和相关感染率
- 批准号:
513901-2017 - 财政年份:2017
- 资助金额:
$ 1.97万 - 项目类别:
Engage Grants Program
Surfactant additions to optimize the anti-biofilm activity of chlorinated disinfectants for industrial cleaning
添加表面活性剂以优化工业清洁用氯化消毒剂的抗生物膜活性
- 批准号:
498418-2016 - 财政年份:2016
- 资助金额:
$ 1.97万 - 项目类别:
Engage Plus Grants Program
Engineering multifunctional hierarchical surface microstructures for bacterial sensing and biofilm prevention
用于细菌传感和生物膜预防的多功能分层表面微结构工程
- 批准号:
435940-2013 - 财政年份:2015
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Surface treatments for food processing surfaces to reduce organic residue and microbial accumulation
食品加工表面的表面处理,以减少有机残留和微生物积累
- 批准号:
488391-2015 - 财政年份:2015
- 资助金额:
$ 1.97万 - 项目类别:
Engage Grants Program
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Engineering multifunctional hierarchical surface microstructures for bacterial sensing and biofilm prevention
用于细菌传感和生物膜预防的多功能分层表面微结构工程
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435940-2013 - 财政年份:2018
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Engineering multifunctional hierarchical surface microstructures for bacterial sensing and biofilm prevention
用于细菌传感和生物膜预防的多功能分层表面微结构工程
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435940-2013 - 财政年份:2015
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Engineering multifunctional hierarchical surface microstructures for bacterial sensing and biofilm prevention
用于细菌传感和生物膜预防的多功能分层表面微结构工程
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435940-2013 - 财政年份:2014
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Discovery Grants Program - Individual