Engineering multifunctional hierarchical surface microstructures for bacterial sensing and biofilm prevention

用于细菌传感和生物膜预防的多功能分层表面微结构工程

• 批准号: 435940-2013
• 负责人: Hatton, Benjamin
• 金额: $ 1.97万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638116
• 关键词: Engineering; multifunctional; hierarchical; surface; microstructures

Natural surfaces, such as plant leaves, and intestinal walls, feature complex microstructures which can respond to their environment, chemically and physically. For example, plants can open and close pores (stomata), and cells can sense chemical stimuli, and move microhairs (cilia) to cause diffusion, move mucus layers, and prevent bacterial adhesion. This proposal is directed towards the design and engineering of responsive microstructured surfaces that can be used to sense chemical species, and physically move arrays of microhairs, or pores, which are based on these biological examples. The active motion of the microhairs can be used to control surface diffusion of chemical species, or the adhesion of particles, or prevent the attachment of bacterial cells. The opening and closing of surface pores can be used to control drug release, or particle capture. Another important design element is the control of optically-tunable metal nanoparticles, which effect the sensitivity of certain quantitative chemical measurements (known as Raman spectroscopy). These moving surface structures will be designed to tune this sensing sensitivity, which could ultimately be very useful for the identification of bacterial strains. In this way, we are designing adaptive, complex surface microstructures that can respond to their environment using biological inspirations.

自然表面，如植物的叶子和肠壁，具有复杂的微观结构，可以在化学和物理上对环境做出反应。例如，植物可以打开和关闭毛孔（气孔），细胞可以感知化学刺激，并移动微毛（纤毛）以引起扩散，移动黏液层，防止细菌粘附。这一建议是针对响应性微结构表面的设计和工程，可用于感知化学物质，并基于这些生物实例物理移动微毛或孔阵列。微毛的主动运动可用于控制化学物质的表面扩散，或颗粒的粘附，或防止细菌细胞的附着。表面孔隙的打开和关闭可用于控制药物释放或颗粒捕获。另一个重要的设计元素是光学可调谐金属纳米颗粒的控制，它会影响某些定量化学测量（称为拉曼光谱）的灵敏度。这些移动的表面结构将被设计来调整这种传感灵敏度，这最终可能对细菌菌株的鉴定非常有用。通过这种方式，我们正在设计自适应的、复杂的表面微观结构，这些结构可以利用生物灵感对环境做出反应。