Ultralow adhesion silicone coatings to reduce rates of biofilm formation and associated infection

超低附着力有机硅涂层可降低生物膜形成率和相关感染率

• 批准号: 513901-2017
• 负责人: Hatton, Benjamin
• 金额: $ 1.82万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=639942
• 关键词: Ultralow; adhesion; silicone; coatings; reduce

'Hospital acquired infections' refer to infections that patients acquire within hospitals due to contaminated medical devices, or dueto procedures that expose healthy tissue to external bacteria. These secondary infections can often be very hard to treat,especially with a recent rise in antibiotic resistance, and can often lead to extended hospital stays, significant healthcare costs andeven death. This project aims to develop silicone-based coatings that have advanced non-fouling and anti-adhesive surfaceproperties, based on a self-lubricating mechanism. We aim to develop these highly non-stick, slippery coatings for medical tubing(catheters) to significantly reduce rates of bacterial attachment to the surface. Our previous results show these surface treatmentsare highly effective, and we believe they could greatly reduce rates of hospital acquired infection.

“医院获得性感染”是指患者在医院内由于受污染的医疗设备或由于将健康组织暴露于外部细菌的程序而获得的感染。这些继发性感染通常很难治疗，特别是最近抗生素耐药性的上升，并且通常会导致住院时间延长，医疗费用增加甚至死亡。该项目旨在开发基于自润滑机制的硅基涂层，该涂层具有先进的无污垢和防粘表面性能。我们的目标是开发这些高度不粘，光滑的涂层用于医疗管（导管），以显着降低细菌附着在表面的比率。我们之前的研究结果表明，这些表面处理非常有效，我们相信它们可以大大降低医院获得性感染率。