Biomechanical Tolerance Criterion for the Spinal Cord

脊髓的生物力学耐受标准

• 批准号: RGPIN-2017-04935
• 负责人: Oxland, Thomas
• 金额: $ 3.21万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638523
• 关键词: Biomechanical; Tolerance; Criterion; Spinal; Cord

Acute spinal cord injury (SCI) begins with a mechanical insult, termed primary injury, followed by an extended biological response, called secondary injury. Research advances over the past decade show, in animal models, that features of the primary injury (e.g. loading rate, direction) have profound influences on the pattern and severity of SCI. Computer simulations of these injuries emphasized the importance of these mechanical effects on tissue damage. These simulations have great potential as design tools for devices and environments for injury prevention (e.g. helmets and automobile interiors). Unfortunately, there exist limitations with these computer models as predictive tools. The main areas for improvement include spinal cord tissue modelling (e.g. grey vs. white matter, anisotropy) and relating the mechanical response to tissue damage (i.e. identifying an appropriate tolerance criterion).

急性脊髓损伤（SCI）开始于机械损伤，称为原发性损伤，随后是扩展的生物反应，称为继发性损伤。过去十年的研究进展表明，在动物模型中，原发性损伤的特征（如加载速率、方向）对SCI的模式和严重程度有深远的影响。这些损伤的计算机模拟强调了这些机械效应对组织损伤的重要性。这些模拟具有很大的潜力，作为设计工具的设备和环境的伤害预防（如头盔和汽车内饰）。不幸的是，这些计算机模型作为预测工具存在局限性。改进的主要领域包括脊髓组织建模（例如，灰质与白色物质、各向异性）以及将机械响应与组织损伤相关联（即，确定适当的公差标准）。