Biomechanical Behaviour of the Spinal Cord

脊髓的生物力学行为

• 批准号: 203784-2012
• 负责人: Oxland, Thomas
• 金额: $ 2.77万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=570003
• 关键词: Biomechanical; Behaviour; Spinal; Cord

My overall research program addresses the manner in which mechanical forces produce spinal cord injury (SCI). The long-term goal of this research program is to determine biomechanical tolerance levels for the spinal cord. The data collected in this process will enable us to differentiate relevant SCI injury mechanisms that occur in people and also enable the design of devices and environments to prevent SCI. The specific objectives of this five-year research program are to i) determine the mechanical parameters (e.g. internal displacements) that correlate best with spinal cord tissue damage over a range of relevant injury conditions) and ii) predict the effect of a range of relevant impact variables on the patterns of spinal cord damage using a mathematical modeling technique termed the finite element method. To address the first specific objective, two parallel approaches will be used. First, relevant SCIs will be produced invivo in rats using our UBC multi-mechanism SCI device. These experiments will be simulated with our current mathematical model and the level of agreement between experiment and simulation will be determined. Based upon the results, the characteristics of the model will be adjusted based upon the literature such that the level of agreement improves. Second, SCIs in rats will be produced across a range of novel conditions using our UBC device. Our finite element model of the rat cervical spine will be used to predict the tissue damage patterns within the cord after this injury. The degree of association between the experiments and the simulations will tell us whether we have a strong predictive model. When successful, we will have identified a biomechanical tolerance criterion for spinal cord tissue. This is important for determining the susceptibility of the spinal cord to mechanical injury under a range of conditions. A thorough knowledge of the mechanics of the injury, combined with a validated FE model, will enable the sub-classification of SCI by injury mechanism and also facilitate the design of devices and environments to prevent SCI.

我的总体研究计划解决了机械力产生脊髓损伤（SCI）的方式。 这项研究计划的长期目标是确定脊髓的生物力学耐受水平。 在此过程中收集的数据将使我们能够区分发生在人体中的相关SCI损伤机制，并使设备和环境的设计能够预防SCI。 这个为期五年的研究计划的具体目标是：i）确定在一系列相关损伤条件下与脊髓组织损伤最相关的力学参数（例如内部位移）; ii）预测一系列相关影响变量的影响使用称为有限元法的数学建模技术对脊髓损伤模式进行研究。 为实现第一个具体目标，将采用两种并行的办法。 首先，将使用我们的UBC多机制SCI装置在大鼠体内产生相关SCI。 这些实验将模拟与我们目前的数学模型和实验和模拟之间的协议水平将被确定。 根据结果，将根据文献调整模型的特征，以提高一致性水平。 其次，将使用我们的UBC设备在一系列新条件下产生大鼠SCI。 我们的大鼠颈椎有限元模型将用于预测脊髓损伤后的组织损伤模式。 实验和模拟之间的关联程度将告诉我们是否有一个强大的预测模型。 当成功时，我们将确定脊髓组织的生物力学耐受标准。 这对于确定脊髓在一系列条件下对机械损伤的敏感性是重要的。 对损伤力学的透彻了解，结合经过验证的有限元模型，将使SCI能够通过损伤机制进行子分类，并有助于设计预防SCI的设备和环境。