Biomechanical behaviour of the spinal cord

脊髓的生物力学行为

• 批准号: 203784-2007
• 负责人: Oxland, Thomas
• 金额: $ 3.13万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=365294
• 关键词: Biomechanical; behaviour; spinal; cord

The overriding hypothesis of this research is that the mechanism of spinal cord injury is critical to the type of damage produced and thus is an important factor that should be incorporated in clinical decision-making.Our major progress over the past several years has highlighted several biomechanical issues that we will explore in the current proposal. Our specific objectives are i) to document the cord deformation patterns that occur in clinically relevant conditions and ii) to simulate patterns of spinal cord damage under these deformation patterns using the finite element method. To address the first specific objective, clinically relevant injuries of will be produced in our novel experimental model at high rates of loading (~1m/s). We will address contusion, fracture-dislocation, and flexion-distraction injuries. During the impact event, the deformation patterns of the spinal column and spinal cord will be monitored using our custom designed high-speed Xray system, which is capable of recording at 1,000 frames per second. To address our second objective, the dynamic cord deformations from the experimental studies will be input to our spinal cord model and the degree of primary damage to the cord tissue will be predicted. The main task involved with the second objective will be to refine our current three-vertebra cervical spine finite element model. Sensitivity studies will be conducted to guide us in this development. Our current strategy is to model the cord structure as a bulk material but the complexity of the problem may force us, in the future, to develop a more anatomically accurate microstructural model of the cord. The accuracy with which we can predict tissue damage patterns in the cord will guide thisresearch. It is anticipated that the main application area for the research will be in the acute stages of clinical treatment, particularly in the technique and timing of surgical intervention as well as the application of  repair/regeneration strategies in this acute setting. Ultimate success of the research will be realized in future clinical translation of the novel methods that demonstrates enhanced outcome for spinal cord injured individuals.

这项研究的首要假设是，脊髓损伤的机制是造成损伤类型的关键，因此是一个重要的因素，应该纳入临床决策。我们在过去几年的主要进展突出了几个生物力学问题，我们将在当前的提案中进行探索。我们的具体目标是：i)记录在临床相关条件下发生的脊髓变形模式；ii)使用有限元方法模拟在这些变形模式下的脊髓损伤模式。为了解决第一个特定的目标，在我们新的实验模型中，将在高负荷率(~1M/S)下产生与临床相关的损伤。我们将处理挫伤、骨折脱位和屈曲牵张损伤。在撞击事件期间，将使用我们定制设计的高速X射线系统监测脊柱和脊髓的变形模式，该系统能够以每秒1000帧的速度进行记录。为了达到我们的第二个目标，实验研究的动态脊髓变形将被输入到我们的脊髓模型中，并将预测对脊髓组织的初始损伤程度。第二个目标涉及的主要任务将是完善我们目前的三椎体颈椎有限元模型。将进行敏感性研究，以指导我们的这一发展。我们目前的策略是将脐带结构建模为大宗材料，但问题的复杂性可能会迫使我们在未来开发更准确的脐带解剖微结构模型。我们预测脐带组织损伤模式的准确性将指导这项研究。预计这项研究的主要应用领域将是临床治疗的急性阶段，特别是在手术干预的技术和时机以及在这种急性情况下应用新的修复/再生策略方面。这项研究的最终成功将在未来新方法的临床翻译中实现，该方法证明了脊髓损伤患者的改善结果。