Identification of Novel Bio-Inks for 3D Printing of Skin

用于皮肤 3D 打印的新型生物墨水的鉴定

• 批准号: 515010-2017
• 负责人: Frampton, John
• 金额: $ 1.82万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=639280
• 关键词: Identification; Novel; Bio; Inks; 3D

This Engage Grant will allow the Frampton Lab at Dalhousie University to assist Aspect Biosystems, theleading Canadian manufacturer of 3D bioprinters, with the development of novel bio-inks for the printing ofhuman skin equivalents. The Frampton lab will examine the growth characteristics of cultured humankeratinocytes (skin cells) in various bio-ink formulations that have potential to be used in the AspectBiosystems 3D bioprinter. With the help of expert technicians from Aspect Biosystems, a set of the mostpromising ink formulations will then be tested for compatibility with the microfluidic cartridges used in theAspect Biosystems 3D bioprinter. The ink formulation that best balances cell growth properties with ease ofprinting will then be utilized to demonstrate bioprinting of stratified epidermal tissues similar to skin.Processed tissue sections of these lab grown skin equivalents will be compared to sections of intact humanskin by histology.

这项资助将允许达尔豪斯大学的弗兰普顿实验室协助加拿大领先的3D生物打印机制造商Aspect Biosystems开发用于打印人体皮肤的新型生物墨水。弗兰普顿实验室将研究在各种生物墨水配方中培养的人类角质形成细胞（皮肤细胞）的生长特性，这些配方有可能用于AspectBiosystems 3D生物打印机。在Aspect Biosystems专业技术人员的帮助下，一组最有前途的墨水配方将被测试与Aspect Biosystems 3D生物打印机中使用的微流体墨盒的兼容性。最佳平衡细胞生长特性和易于打印的油墨配方将用于演示类似皮肤的分层表皮组织的生物打印。这些实验室生长的皮肤等效物的处理组织切片将通过组织学与完整的人类皮肤切片进行比较。