Assembly of Biomaterials in Multiphase Liquid Systems

多相液体系统中生物材料的组装

• 批准号: RGPIN-2016-04298
• 负责人: Frampton, John
• 金额: $ 2.4万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=684542
• 关键词: Assembly; Biomaterials; Multiphase; Liquid; Systems

This research will develop strategies for building models of biological tissues in the laboratory. My laboratory will use sets of water-based materials that spontaneously separate from one another (much like oil and water mixtures) to confine the biological components required to build these models and organize them into useful configurations. The unique properties of these systems will eliminate practical constraints imposed by machine-based approaches. An essential step to achieving this long term goal will be to identify useful materials that display separation and assembly behavior. To identify these materials, a variety of synthetic and natural polymers will be screened to select systems with multiple separate zones (phases) that promote the arrangement (self-assembly) of tissue building-blocks. These systems will be used to build models of tissue interfaces, for example, the regions in the body where the muscular and the skeletal system meet and the various tissues of the body that serve as barriers (for example, the skin and gut). This technology will lead to the development of better models for understanding biological processes and pharmaceutical/toxin testing.**

这项研究将制定在实验室构建生物组织模型的策略。我的实验室将使用一组自发地彼此分离的水基材料（很像油和水的混合物）来限制构建这些模型所需的生物成分，并将它们组织成有用的配置。这些系统的独特属性将消除基于机器的方法所施加的实际限制。实现这一长期目标的一个重要步骤是识别具有分离和组装行为的有用材料。为了识别这些材料，将筛选各种合成和天然聚合物，以选择具有多个单独区域（相）的系统，以促进组织构建块的排列（自组装）。这些系统将用于构建组织界面模型，例如体内肌肉和骨骼系统相遇的区域以及充当屏障的身体各种组织（例如皮肤和肠道）。这项技术将有助于开发更好的模型来理解生物过程和药物/毒素测试。**