Investigating a Regulator of the Retromer Sorting Pathway to Develop Therapeutic Targets in Late-Onset Parkinson's Disease

研究逆转录酶分选途径的调节因子以开发迟发性帕金森病的治疗靶点

• 批准号: 386493
• 负责人: Shortill Shawn P
• 金额: $ 1.27万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-12-01 至 2018-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=386493&lang=en
• 关键词: Alzheimer'S Disease; Biochemistry; Cell Biology; Cell Sorting Defects; High-Throughput Screening; Intracellular Trafficking; Medical Genetics; Parkinson'S Disease; Signal Transduction; Yeast Genetics

The coordinated and timely delivery of protein cargos to their intended cellular destinations is an important part of normal cellular function, and perturbations to these sorting pathways can result in disease. The retromer sorting pathway, for example, i

协调和及时地将蛋白质货物运送到预定的细胞目的地是正常细胞功能的重要组成部分，对这些分选途径的干扰可能导致疾病。例如，逆转录排序途径为i