Synthesis of TRIOZAN-Peptide Conjugates as Blood-Brain Transient Drug Nanovector
Synthesis of TRIOZAN-Peptide Conjugates as Blood-Brain Transient Drug Nanovector
作为血脑瞬时药物纳米载体的 TRIOZAN-肽缀合物的合成
批准号：
511143-2017
负责人：
Dory, Yves
金额：
$1.82万
依托单位：
依托单位国家：
加拿大
项目类别：
Engage Grants Program
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-01-01 至 2018-12-31
中文摘要
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英文摘要
In spite of considerable advancement in cancer chemotherapy, the survival rate in brain cancer patients isextremely limited mainly due to the blood-brain barrier (BBB) which prevents the transmission of drug fromblood circulation into the brain parenchyma. The present research proposal is based on the conjugation ofTRIOZANTM, as a nanomedicine delivery platform under proprietary of Ovensa Inc., with B1R agonist ligand.The permeability of B1R-functionalized TRIOZANTM will be evaluated via the measurement of its bindingaffinity to the endothelial cell receptors. Developed technology will be transferred to Ovensa Inc. as a key stepin developing of blood-brain-transient drug delivery platform.
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Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres
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批准号：RGPIN-2017-05409
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项目类别：Discovery Grants Program - Individual
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资助金额：$2.04万
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财政年份：2022
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负责人：Dory, Yves
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依托单位：
Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres
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批准号：RGPIN-2017-05409
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项目类别：Discovery Grants Program - Individual
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资助金额：$2.04万
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财政年份：2021
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负责人：Dory, Yves
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依托单位：
Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres
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批准号：RGPIN-2017-05409
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项目类别：Discovery Grants Program - Individual
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资助金额：$2.04万
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财政年份：2020
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负责人：Dory, Yves
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依托单位：
Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres
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批准号：RGPIN-2017-05409
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项目类别：Discovery Grants Program - Individual
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资助金额：$2.04万
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财政年份：2019
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负责人：Dory, Yves
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依托单位：
Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres
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批准号：RGPIN-2017-05409
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项目类别：Discovery Grants Program - Individual
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资助金额：$2.04万
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财政年份：2018
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负责人：Dory, Yves
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依托单位：
Design, preparation and biological evaluation of libraries of marocyclic delta opioid receptor agonists for the treatment of pain
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批准号：468428-2014
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项目类别：Collaborative Research and Development Grants
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资助金额：$3.15万
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财政年份：2017
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负责人：Dory, Yves
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依托单位：
Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres
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批准号：RGPIN-2017-05409
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项目类别：Discovery Grants Program - Individual
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资助金额：$2.04万
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财政年份：2017
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负责人：Dory, Yves
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依托单位：
Design, preparation and biological evaluation of libraries of marocyclic delta opioid receptor agonists for the treatment of pain
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批准号：468428-2014
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项目类别：Collaborative Research and Development Grants
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资助金额：$3.15万
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财政年份：2016
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负责人：Dory, Yves
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依托单位：
Theoretical design, synthesis and characterization of novel organic self-assembling materials. Conception, Synthèse et Caractérisation de Nouveaux Matériaux Auto-Assemblés.
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批准号：218405-2011
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项目类别：Discovery Grants Program - Individual
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资助金额：$2.55万
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财政年份：2015
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负责人：Dory, Yves
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依托单位：
Design, preparation and biological evaluation of libraries of marocyclic delta opioid receptor agonists for the treatment of pain
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批准号：468428-2014
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项目类别：Collaborative Research and Development Grants
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资助金额：$3.16万
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财政年份：2015
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负责人：Dory, Yves
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依托单位：
Theoretical design, synthesis and characterization of novel organic self-assembling materials. Conception, Synthèse et Caractérisation de Nouveaux Matériaux Auto-Assemblés.
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批准号：218405-2011
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项目类别：Discovery Grants Program - Individual
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资助金额：$2.55万
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财政年份：2014
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负责人：Dory, Yves
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依托单位：
Theoretical design, synthesis and characterization of novel organic self-assembling materials. Conception, Synthèse et Caractérisation de Nouveaux Matériaux Auto-Assemblés.
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批准号：218405-2011
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项目类别：Discovery Grants Program - Individual
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资助金额：$2.55万
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财政年份：2013
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负责人：Dory, Yves
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依托单位：
Theoretical design, synthesis and characterization of novel organic self-assembling materials. / Conception, Synthèse et Caractérisation de Nouveaux Matériaux Auto-Assemblés.
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批准号：218405-2011
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项目类别：Discovery Grants Program - Individual
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资助金额：$2.55万
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财政年份：2012
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负责人：Dory, Yves
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依托单位：
Peptide synthesizer for research in pharmacology and medicinal chemistry. Synthétiseur de peptides pour la recherche en pharmacologie et chimie médicinale.
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批准号：423423-2012
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项目类别：Research Tools and Instruments - Category 1 (<$150,000)
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资助金额：$7.33万
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财政年份：2011
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负责人：Dory, Yves
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依托单位：
Theoretical design, synthesis and characterization of novel organic self-assembling materials. Conception, Synthèse et Caractérisation de Nouveaux Matériaux Auto-Assemblés.
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批准号：218405-2011
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项目类别：Discovery Grants Program - Individual
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资助金额：$2.55万
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财政年份：2011
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负责人：Dory, Yves
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依托单位：
Theoretical design, synthesis and characterization of novel organic self-assembling materials conception, synthèse et caractérisation de nouveaux matériaux auto-assemblés
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批准号：218405-2005
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项目类别：Discovery Grants Program - Individual
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资助金额：$3.28万
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财政年份：2009
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负责人：Dory, Yves
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依托单位：
Theoretical design, synthesis and characterization of novel organic self-assembling materials conception, synthèse et caractérisation de nouveaux matériaux auto-assemblés
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批准号：218405-2005
-
项目类别：Discovery Grants Program - Individual
-
资助金额：$3.28万
-
财政年份：2008
-
负责人：Dory, Yves
-
依托单位：
Theoretical design, synthesis and characterization of novel organic self-assembling materials conception, synthèse et caractérisation de nouveaux matériaux auto-assemblés
-
批准号：218405-2005
-
项目类别：Discovery Grants Program - Individual
-
资助金额：$3.28万
-
财政年份：2007
-
负责人：Dory, Yves
-
依托单位：
Theoretical design, synthesis and characterization of novel organic self-assembling materials conception, synthèse et caractérisation de nouveaux matériaux auto-assemblés
-
批准号：218405-2005
-
项目类别：Discovery Grants Program - Individual
-
资助金额：$3.28万
-
财政年份：2006
-
负责人：Dory, Yves
-
依托单位：
Theoretical design, synthesis and characterization of novel organic self-assembling materials conception, synthèse et caractérisation de nouveaux matériaux auto-assemblés
-
批准号：218405-2005
-
项目类别：Discovery Grants Program - Individual
-
资助金额：$3.28万
-
财政年份：2005
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负责人：Dory, Yves
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依托单位：