Design, preparation and biological evaluation of libraries of marocyclic delta opioid receptor agonists for the treatment of pain

用于治疗疼痛的大环δ阿片受体激动剂库的设计、制备和生物学评价

• 批准号: 468428-2014
• 负责人: Dory, Yves
• 金额: $ 3.15万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=598276
• 关键词: Design; preparation; biological; evaluation; libraries

The overall goal of this research proposal is to provide novel peptide-based DOPr (delta opioid receptor) agonists for the treatment of chronic pain. Although numerous peptide and non-peptide DOPr agonists have been developed over the past 30 years, very few compounds have reached clinical trials and, most importantly, nowadays none of them have been approved for clinical use.

本研究的总体目标是提供新的基于肽的DOPr（δ阿片受体）激动剂用于治疗慢性疼痛。尽管在过去的30年中已经开发了许多肽和非肽DOPr激动剂，但很少有化合物达到临床试验，最重要的是，现在它们中没有一个被批准用于临床使用。