Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres
自组装纳米管和纳米球的设计、合成和表征
基本信息
- 批准号:RGPIN-2017-05409
- 负责人:
- 金额:$ 2.04万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The goal of the program is to obtain several new organic clusters having controlled shapes, tubes and spheres, through predicted self-assembly. The tubular and spherical clusters that we are targeting are held together by means of weak interactions: H-bonds and van der Walls contacts.****** Most sub-units leading to tubes have C3, Ci and S2 symmetry and are either cyclic peptides made from unusual amino-acids or polyamides of cis geometry. The cyclic peptides sub-units can stack on top of each other to generate wires or tubes having either very strong dipoles like alpha helices or no dipole at all. *** The other type of sub-units having disk shapes can either form sheets like graphite or balls of T, O or I symmetry, like buckminsterfullerene, that could encapsulate metals and other molecular objects. ***Supermolecules of these types could have direct applications in many areas of research and technology such as biological transport, drug delivery, sensing, non-linear optics, conductivity, photonics, gels and other new materials, catalysis…****** The program is based on an iterative process involving all the following steps to finally get a complete structure – properties relationship chart:***Step 1) The sub-units will be carefully designed and their self-assembly will be studied by molecular modelling. ***Step 2) The synthesis of the sub-units will be carried out in the laboratory.***Step 3) Their self-assembly and the properties of the supramolecular architectures will be studied with several modern techniques, like NMR, MS, SEM, TEM, crystallography, etc.***Step 4) Analysis of the results will either lead to useful supramolecules (that can be published and/or find applications) or necessitate a fine tuning, in which case the process will be restarted (step 1) with accumulated knowledge.
该计划的目标是通过预测的自组装,获得几种具有可控形状、管状和球形的新有机团簇。我们瞄准的管状和球形团簇是通过弱相互作用(氢键和范德沃尔斯接触)结合在一起的。******大多数通向管的亚基具有C3, Ci和S2对称,并且是由不寻常的氨基酸或顺式几何聚酰胺制成的环状肽。环状肽亚基可以堆叠在一起,形成像螺旋一样具有很强偶极子的线或管,或者根本没有偶极子。另一种具有圆盘形状的亚基可以像石墨一样形成薄片,也可以像巴克敏斯特富勒烯一样形成T、O或I对称的球,可以封装金属和其他分子物体。这些类型的超分子可以直接应用于许多研究和技术领域,如生物运输、药物输送、传感、非线性光学、电导率、光子学、凝胶和其他新材料。催化…******该计划是基于一个迭代过程,包括所有以下步骤,最终得到一个完整的结构-性质关系图:***步骤1)将仔细设计亚基,并通过分子模型研究它们的自组装。***步骤2)亚基的合成将在实验室进行。***步骤3)它们的自组装和超分子结构的性质将使用几种现代技术进行研究,如NMR, MS, SEM, TEM,晶体学等。***步骤4)结果的分析将导致有用的超分子(可以发表和/或找到应用)或需要微调,在这种情况下,该过程将重新启动(步骤1)积累的知识。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Dory, Yves其他文献
Evaluation of Novel B1R/B2R Agonists Containing TRIOZAN™ Nanoparticles for Targeted Brain Delivery of Antibodies in a Mouse Model of Alzheimer Disease.
- DOI:
10.3390/molecules28135206 - 发表时间:
2023-07-04 - 期刊:
- 影响因子:4.6
- 作者:
Gagnon, Maxime;Savard, Martin;Tran, Thi Minh Hue;Vincent, Laurence;Moquin, Alexandre;Tremblay, Philippe;Roucou, Xavier;Dory, Yves;Gobeil, Fernand - 通讯作者:
Gobeil, Fernand
Dory, Yves的其他文献
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{{ truncateString('Dory, Yves', 18)}}的其他基金
Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres
自组装纳米管和纳米球的设计、合成和表征
- 批准号:
RGPIN-2017-05409 - 财政年份:2022
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres
自组装纳米管和纳米球的设计、合成和表征
- 批准号:
RGPIN-2017-05409 - 财政年份:2021
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres
自组装纳米管和纳米球的设计、合成和表征
- 批准号:
RGPIN-2017-05409 - 财政年份:2020
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres
自组装纳米管和纳米球的设计、合成和表征
- 批准号:
RGPIN-2017-05409 - 财政年份:2019
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Design, preparation and biological evaluation of libraries of marocyclic delta opioid receptor agonists for the treatment of pain
用于治疗疼痛的大环δ阿片受体激动剂库的设计、制备和生物学评价
- 批准号:
468428-2014 - 财政年份:2017
- 资助金额:
$ 2.04万 - 项目类别:
Collaborative Research and Development Grants
Design, Synthesis and Characterization of Self-Assembling Nanotubes and Nanospheres
自组装纳米管和纳米球的设计、合成和表征
- 批准号:
RGPIN-2017-05409 - 财政年份:2017
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Synthesis of TRIOZAN-Peptide Conjugates as Blood-Brain Transient Drug Nanovector
作为血脑瞬时药物纳米载体的 TRIOZAN-肽缀合物的合成
- 批准号:
511143-2017 - 财政年份:2017
- 资助金额:
$ 2.04万 - 项目类别:
Engage Grants Program
Design, preparation and biological evaluation of libraries of marocyclic delta opioid receptor agonists for the treatment of pain
用于治疗疼痛的大环δ阿片受体激动剂库的设计、制备和生物学评价
- 批准号:
468428-2014 - 财政年份:2016
- 资助金额:
$ 2.04万 - 项目类别:
Collaborative Research and Development Grants
Theoretical design, synthesis and characterization of novel organic self-assembling materials. Conception, Synthèse et Caractérisation de Nouveaux Matériaux Auto-Assemblés.
新型有机自组装材料的理论设计、合成与表征。
- 批准号:
218405-2011 - 财政年份:2015
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Design, preparation and biological evaluation of libraries of marocyclic delta opioid receptor agonists for the treatment of pain
用于治疗疼痛的大环δ阿片受体激动剂库的设计、制备和生物学评价
- 批准号:
468428-2014 - 财政年份:2015
- 资助金额:
$ 2.04万 - 项目类别:
Collaborative Research and Development Grants
相似国自然基金
新型滤波器综合技术-直接综合技术(Direct synthesis Technique)的研究及应用
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