Synthesis of Novel Sugar-Nucleic Acid Polymers

新型糖-核酸聚合物的合成

• 批准号: 521984-2017
• 负责人: Desaulniers, JeanPaul
• 金额: $ 1.82万
• 依托单位: University of Ontario Institute of Technology
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=640175
• 关键词: Synthesis; Novel; Sugar; Nucleic; Acid

Natural molecules like DNA and RNA are sugar-nucleic acid polymers that have desirable biological function.However, expanding the applications of sugar-nucleic acid polymers are needed for downstreambiotechnological applications because natural DNA and RNA are susceptible to degradation in the biologicalenvironment. Synthose is a company that specializes in the chemistry of sugars. Synthose has interests inexpanding their platform to nucleic acids. Based on the expertise of Synthose in sugar chemistry, and theexpertise in nucleic acid chemistry by Dr. Desaulniers' research group at the University of Ontario Institute ofTechnology (UOIT), new proposed sugar-nucleic acid polymers will be synthesized and studied. The workdescribed will foster a new collaboration between the UOIT and the chemical industry sector and will generateunique structures that may have interesting future commercial value. As such, the new knowledge gainedthrough the development of new sugar-nucleic acid polymers will offer exciting potential for the chemistry andbiotechnology fields.

像DNA和RNA这样的天然分子是具有理想生物功能的糖-核酸聚合物。然而，由于天然DNA和RNA在生物环境中容易降解，因此下游生物技术应用需要扩大糖核酸聚合物的应用范围。Synthose是一家专门从事糖化学的公司。syn那些有兴趣将他们的平台扩展到核酸。基于Synthose在糖化学方面的专业知识，以及安大略省理工大学（UOIT） Desaulniers博士研究小组在核酸化学方面的专业知识，新的糖-核酸聚合物将被合成和研究。所描述的工作将促进uit和化学工业部门之间的新合作，并将产生独特的结构，可能具有有趣的未来商业价值。因此，通过开发新的糖核酸聚合物获得的新知识将为化学和生物技术领域提供令人兴奋的潜力。