New chemical approaches in modifying short interfering RNAs
New chemical approaches in modifying short interfering RNAs
批准号:
371537-2009
负责人:
Desaulniers, JeanPaul
金额:
$2.33万
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-01-01 至 2014-12-31
中文摘要
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英文摘要
This research program investigates new approaches for lowering the expression level of a particular gene using the natural RNA interference (RNAi) pathway. Since controlled gene expression levels are essential for proper biological function, the ability to silence or control the expression of genes is highly desirable. The RNAi pathway is a natural biological process that relies on short double-stranded RNAs to target gene specific messenger RNA. The potential of harnessing this natural pathway would have enormous impact on research and medicine worldwide, including Canada. However, the main pitfalls prohibiting the success of natural double-stranded RNAs as silencing agents are a) short-lifetime; b) toxicity and off-target effects; c) and poor cell-membrane permeability.
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依托单位:
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批准号:RGPIN-2019-04692
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.11万
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财政年份:2020
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负责人:Desaulniers, JeanPaul
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依托单位:
Synthesis and Applications of Chemically-Modified Oligonucleotides
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批准号:RGPIN-2019-04692
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.11万
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财政年份:2019
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负责人:Desaulniers, JeanPaul
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依托单位:
Synthesis of Chemically-Modified Biological Molecules
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批准号:536203-2018
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项目类别:Collaborative Research and Development Grants
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资助金额:$1.89万
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批准号:RGPIN-2014-04127
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Photoresponsive siRNAs as a biotechnological tool to examine gene function
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依托单位:
Synthesis and investigation of chemically-modified oligonucleotides as gene-silencing substrates
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批准号:RGPIN-2014-04127
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
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Synthesis and investigation of chemically-modified oligonucleotides as gene-silencing substrates
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Synthesis and investigation of chemically-modified oligonucleotides as gene-silencing substrates
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批准号:RGPIN-2014-04127
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
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财政年份:2015
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依托单位:
Synthesis and investigation of chemically-modified oligonucleotides as gene-silencing substrates
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批准号:RGPIN-2014-04127
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.19万
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财政年份:2014
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负责人:Desaulniers, JeanPaul
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依托单位:
Synthesis and Evaluation of Chemically-Modified siRNAs that Target bcl-2
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批准号:451441-2013
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项目类别:Engage Grants Program
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资助金额:$1.82万
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财政年份:2013
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负责人:Desaulniers, JeanPaul
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依托单位:
New chemical approaches in modifying short interfering RNAs
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批准号:371537-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.33万
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财政年份:2012
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负责人:Desaulniers, JeanPaul
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依托单位:
New chemical approaches in modifying short interfering RNAs
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批准号:371537-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.33万
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财政年份:2011
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负责人:Desaulniers, JeanPaul
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依托单位:
New chemical approaches in modifying short interfering RNAs
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批准号:371537-2009
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项目类别:Discovery Grants Program - Individual
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资助金额:$1.97万
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财政年份:2010
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负责人:Desaulniers, JeanPaul
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依托单位:
New chemical approaches in modifying short interfering RNAs
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批准号:371537-2009
-
项目类别:Discovery Grants Program - Individual
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资助金额:$1.97万
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财政年份:2009
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负责人:Desaulniers, JeanPaul
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依托单位:
国内基金
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