Mechanical evaluation of delivery systems for non-antibiotic antimicrobial solutions

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Hard to treat bacteria, particularly antibiotic-resistant bacteria, and associated infections impose a great burdenon the Canadian healthcare system. SterileCare Inc. produces an antibacterial alternative to antibiotics which iseffective against antibiotic-resistant bacteria. Their product, KiteLock solution, is approved Health Canada todecrease the risk of bacterial growth within catheters. To use KiteLock, users (nurses and patients) manuallytwist-off the end of a vial (which KiteLock is stored in), withdraw the solution from the vial into a disposablesyringe, and then introduce the solution into the catheter. Currently, the vial is difficult to open due to therigidity of the resin as well as the vial design. This is causing users to struggle with opening of the vial, causingfracture away from the intended break-off point, resulting in product waste and reduced market traction andcredibility.The overall goal of this NSERC Engage Grant is to aid SterileCare with production issues related to theirKiteLock delivery system as well as investigate functionality and compatibility of other potential deliverysystems (specifically existing syringes and catheters). To accomplish this goal, the main objectives are to: (1)develop computational finite element models of the current vial design to identify alternate designs forappropriate tip twist-off; (2) communicate with SterileCare and the contract manufacturer of the vials toproduce and evaluate alternate designs; and (3) conduct mechanical testing of standard syringes and catheterswhen exposed to KiteLock solution.The outcomes of this research will mitigate end-user frustration found with KiteLock, which will lead tomore hospitals adopting the product. This will lead to reduced antibiotic use and a reduction of antibioticresistance, two major health issues affecting Canadians. As well, this research will provide direction foralternate delivery systems. Further, trainees involved in this research will interact with industry and obtaintraining in medical device design.