Mechanical evaluation of delivery systems for non-antibiotic antimicrobial solutions

非抗生素抗菌溶液输送系统的机械评估

• 批准号: 513889-2017
• 负责人: Johnston, James
• 金额: $ 1.82万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=640627
• 关键词: Mechanical; evaluation; delivery; systems; non

Hard to treat bacteria, particularly antibiotic-resistant bacteria, and associated infections impose a great burdenon the Canadian healthcare system. SterileCare Inc. produces an antibacterial alternative to antibiotics which iseffective against antibiotic-resistant bacteria. Their product, KiteLock solution, is approved Health Canada todecrease the risk of bacterial growth within catheters. To use KiteLock, users (nurses and patients) manuallytwist-off the end of a vial (which KiteLock is stored in), withdraw the solution from the vial into a disposablesyringe, and then introduce the solution into the catheter. Currently, the vial is difficult to open due to therigidity of the resin as well as the vial design. This is causing users to struggle with opening of the vial, causingfracture away from the intended break-off point, resulting in product waste and reduced market traction andcredibility.The overall goal of this NSERC Engage Grant is to aid SterileCare with production issues related to theirKiteLock delivery system as well as investigate functionality and compatibility of other potential deliverysystems (specifically existing syringes and catheters). To accomplish this goal, the main objectives are to: (1)develop computational finite element models of the current vial design to identify alternate designs forappropriate tip twist-off; (2) communicate with SterileCare and the contract manufacturer of the vials toproduce and evaluate alternate designs; and (3) conduct mechanical testing of standard syringes and catheterswhen exposed to KiteLock solution.The outcomes of this research will mitigate end-user frustration found with KiteLock, which will lead tomore hospitals adopting the product. This will lead to reduced antibiotic use and a reduction of antibioticresistance, two major health issues affecting Canadians. As well, this research will provide direction foralternate delivery systems. Further, trainees involved in this research will interact with industry and obtaintraining in medical device design.

很难治疗细菌，特别是抗药性细菌，以及相关的感染给加拿大的医疗系统带来了巨大的负担。SterileCare公司生产一种抗生素的抗菌剂替代品，对抗药性细菌有效。他们的产品KiteLock溶液获得加拿大卫生部批准，可以降低导管内细菌生长的风险。使用KiteLock时，使用者(护士和病人)手动拧开小瓶(存放KiteLock)的末端，将溶液从小瓶中取出，放入一次性注射器中，然后将溶液引入导管。目前，由于树脂的硬度以及瓶子的设计，瓶子很难打开。这导致用户难以打开小瓶，导致远离预定断点的骨折，导致产品浪费，降低市场吸引力和可信度。NSERC Engage Grant的总体目标是帮助SterileCare解决与他们的Kit Lock递送系统相关的生产问题，并调查其他潜在递送系统(特别是现有注射器和导管)的功能和兼容性。为了实现这一目标，主要目标是：(1)开发当前瓶子设计的计算有限元模型，以确定合适的尖端扭转的替代设计；(2)与SterileCare和瓶子的合同制造商沟通，以产生和评估替代设计；以及(3)对暴露于KiteLock解决方案的标准注射器和导管进行机械测试。本研究的结果将缓解终端用户对KiteLock的失望，这将导致更多的医院采用该产品。这将导致减少抗生素的使用和减少抗生素耐药性，这是影响加拿大人的两个主要健康问题。同时，这项研究也将为替代递送系统提供方向。此外，参与这项研究的学员将与行业互动，并获得医疗器械设计方面的培训。