High-throughput measurement of visuomotor control for complex movement

复杂运动视觉运动控制的高通量测量

• 批准号: RTI-2018-00142
• 负责人: Altshuler, Douglas
• 金额: $ 10.65万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642190
• 关键词: throughput; measurement; visuomotor; control; complex

A key role of the brain is to control movement. Because most neuroscience research occurs in restricted preparations, there is a gap in our understanding of the control of complex motions required for free movement. Maneuverability is critical for survival, and susceptible to disease, injury, and ageing. What behaviour is likely to provide the greatest insight into fundamental algorithms for complex motion control? Animals moving through water or on land are greatly assisted by passive stabilizing mechanisms of buoyancy and ground reaction, respectively. My laboratory focuses on flight because it requires precise control in all degrees of freedom. Most other groups taking this approach work with fruit flies because of molecular tools available to manipulate their nervous system. However, fly brains are too small to study outside of tethered preparations.

大脑的一个关键作用是控制运动。由于大多数神经科学研究都是在有限的准备工作中进行的，因此我们对自由运动所需的复杂运动控制的理解存在差距。机动性对于生存至关重要，并且容易受到疾病，受伤和老化的影响。什么行为可能为复杂运动控制的基本算法提供最大的洞察力？在水中或陆地上移动的动物分别受到浮力和地面反应的被动稳定机制的极大帮助。我的实验室专注于飞行，因为它需要在所有自由度上进行精确控制。大多数采用这种方法的其他研究小组与果蝇一起工作，因为分子工具可以操纵它们的神经系统。然而，苍蝇的大脑太小，无法在系留的准备工作之外进行研究。