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Ion Mobility Mass Spectrometer for Studying Protein Structure and Dynamics

Ion Mobility Mass Spectrometer for Studying Protein Structure and Dynamics
用于研究蛋白质结构和动力学的离子淌度质谱仪
批准号:
RTI-2018-00388
负责人:
Konermann, Lars
金额:
$10.92万
依托单位国家:
加拿大
项目类别:
Research Tools and Instruments
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31

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中文摘要
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英文摘要
We request an urgently needed ion mobility mass spectrometry (IM/MS) instrument for hydrogen/deuterium exchange (HDX) measurements that will elucidate the role of proteins in health and disease. HDX techniques are essential for probing protein dynamics. Flexible segments undergo rapid HDX, while deuteration in folded regions is slow. This information is complementary to data from X-ray crystallography, cryo-electron microscopy, and NMR spectroscopy. HDX techniques have the unique advantage that they can report on functionally important protein dynamics
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Protein Structure and Dynamics Studied by Mass Spectrometry
  • 批准号:
    RGPIN-2018-04243
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $8.81万
  • 财政年份:
    2022
  • 负责人:
    Konermann, Lars
  • 依托单位:
Protein Structure and Dynamics Studied by Mass Spectrometry
  • 批准号:
    RGPIN-2018-04243
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $8.81万
  • 财政年份:
    2021
  • 负责人:
    Konermann, Lars
  • 依托单位:
Protein Structure and Dynamics Studied by Mass Spectrometry
  • 批准号:
    RGPIN-2018-04243
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $8.81万
  • 财政年份:
    2020
  • 负责人:
    Konermann, Lars
  • 依托单位:
Protein Structure and Dynamics Studied by Mass Spectrometry
  • 批准号:
    RGPIN-2018-04243
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $8.81万
  • 财政年份:
    2019
  • 负责人:
    Konermann, Lars
  • 依托单位:
海外基金