Integration of Multiphase Hydrodynamics, Metabolic Modelling, and Control to enable Simulation-based Design of Bioreactors
集成多相流体动力学、代谢建模和控制,实现生物反应器的基于仿真的设计
基本信息
- 批准号:538642-2019
- 负责人:
- 金额:$ 3.76万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Collaborative Research and Development Grants
- 财政年份:2021
- 资助国家:加拿大
- 起止时间:2021-01-01 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The use of biological processes in engineering and science has resulted in disruptive medical advances ranging from personalized cell-based therapies (CAR-T cell therapy) to large-scale production of vaccines, both of which contribute to prolonging human life. Today's vaccine market is expected to reach $50 billion by 2020, creating a clear need for efficient, large-scale vaccine production. Biological processes used for vaccine manufacturing generally rely on the design, operation, and optimization of bioreactors. However, bioreactors are very complex unit operations that combine multiphase (gas-liquid-solid) multicomponent hydrodynamics, interphase mass transport, and metabolic reactions. Sanofi Pasteur, the largest manufacturer of vaccines worldwide, uses bioprocesses/bioreactors to develop and manufacture vaccines for the Canadian and global markets. Their in-house research and development facilities would benefit from the development of theoretical models and computational simulations to improve their design processes and operations. They are in an ideal position to leverage advances in these areas and, ultimately, a simultaneous design/control process to improve their manufacturing operations. The proposed research project aims to increase production efficiencies by developing multiphase multiphysics models, integrating advanced multivariable control schemes into simulations using these models, and applying these methods in collaboration with Sanofi Pasteur's research and development group. The outcome of the proposed work would significantly contribute to our understanding of bioreactor multiphysics processes and enable Sanofi and the vaccine industry, to predict the performance and dynamics of bioreactors and other bioprocesses under multivariable control with minimal capital costs and time expenditure.
生物过程在工程和科学中的应用带来了颠覆性的医学进步,从基于细胞的个性化疗法(CAR-T细胞疗法)到疫苗的大规模生产,这两者都有助于延长人类寿命。目前的疫苗市场预计到2020年将达到500亿美元,这显然需要高效、大规模的疫苗生产。用于疫苗生产的生物工艺通常依赖于生物反应器的设计、操作和优化。然而,生物反应器是非常复杂的单元操作,其结合了联合收割机多相(气-液-固)多组分流体力学、相间质量传输和代谢反应。 Sanofi Pasteur是全球最大的疫苗制造商,使用生物工艺/生物反应器为加拿大和全球市场开发和制造疫苗。它们的内部研究和开发设施将受益于理论模型和计算模拟的开发,以改进它们的设计过程和运作。他们处于理想的位置,可以利用这些领域的进步,并最终通过同步设计/控制过程来改善其制造业务。 拟议的研究项目旨在通过开发多相多物理场模型,将先进的多变量控制方案集成到使用这些模型的模拟中,并与赛诺菲巴斯德的研发团队合作应用这些方法来提高生产效率。 拟议工作的结果将大大有助于我们对生物反应器多物理场过程的理解,并使赛诺菲和疫苗行业能够以最小的资本成本和时间支出预测多变量控制下生物反应器和其他生物过程的性能和动态。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Abukhdeir, NasserMohieddin其他文献
Abukhdeir, NasserMohieddin的其他文献
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{{ truncateString('Abukhdeir, NasserMohieddin', 18)}}的其他基金
Integration of Multiphase Hydrodynamics, Metabolic Modelling, and Control to enable Simulation-based Design of Bioreactors
集成多相流体动力学、代谢建模和控制,实现生物反应器的基于仿真的设计
- 批准号:
538642-2019 - 财政年份:2020
- 资助金额:
$ 3.76万 - 项目类别:
Collaborative Research and Development Grants
Simulation-based Scale-up of Bioreactors using Computational Multiphysics
使用计算多物理场进行基于模拟的生物反应器放大
- 批准号:
523521-2018 - 财政年份:2018
- 资助金额:
$ 3.76万 - 项目类别:
Engage Grants Program
Simulation-based Analysis and Design of Polydisperse Fluidized Bed Reactors
多分散流化床反应器的仿真分析与设计
- 批准号:
531184-2018 - 财政年份:2018
- 资助金额:
$ 3.76万 - 项目类别:
Collaborative Research and Development Grants
Simulation-based Engineering of Micro/Nanoscale Liquid Crystal Devices
基于仿真的微/纳米级液晶器件工程
- 批准号:
418353-2012 - 财政年份:2017
- 资助金额:
$ 3.76万 - 项目类别:
Discovery Grants Program - Individual
Simulation-based Design of Fluidized Bed Reactors for Wastewater Treatment
基于仿真的废水处理流化床反应器设计
- 批准号:
514483-2017 - 财政年份:2017
- 资助金额:
$ 3.76万 - 项目类别:
Engage Grants Program
Simulation-based Design of Fluidized Bed Reactors for Wastewater Treatment
基于仿真的废水处理流化床反应器设计
- 批准号:
520965-2017 - 财政年份:2017
- 资助金额:
$ 3.76万 - 项目类别:
Engage Plus Grants Program
Site visit for the identification of collaborative opportunities in the design of fluidized bed reactors for wastewater treatment
实地考察以确定废水处理流化床反应器设计中的合作机会
- 批准号:
506803-2016 - 财政年份:2016
- 资助金额:
$ 3.76万 - 项目类别:
Connect Grants Level 1
Simulation-based Engineering of Micro/Nanoscale Liquid Crystal Devices
基于仿真的微/纳米级液晶器件工程
- 批准号:
418353-2012 - 财政年份:2016
- 资助金额:
$ 3.76万 - 项目类别:
Discovery Grants Program - Individual
Simulation-assisted design and optimization of multiphase unit operations for Canadian bitumen processing
加拿大沥青加工多相单元操作的仿真辅助设计和优化
- 批准号:
470597-2014 - 财政年份:2015
- 资助金额:
$ 3.76万 - 项目类别:
Collaborative Research and Development Grants
Simulation-based analysis of phase-change cooling mechanisms for integral molten salt reactors
基于仿真的整体熔盐反应堆相变冷却机制分析
- 批准号:
478377-2015 - 财政年份:2015
- 资助金额:
$ 3.76万 - 项目类别:
Engage Grants Program
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