Mechanistic understanding of the thermosensitive Transient Receptor Potential (TRP) channels.
对热敏瞬时受体电位 (TRP) 通道的机制了解。
基本信息
- 批准号:RGPIN-2015-06715
- 负责人:
- 金额:$ 2.19万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Transient Receptor Potential (TRP) Channels are transmembrane proteins that detect and transduce physical and chemical stimuli. They are involved in various sensory function of the nervous system including vision, taste, pain perception and thermosensation. My research program focuses on the molecular pharmacology of the Thermosensitive families of TRP channel that detect heat, cold and warm temperature. At the molecular level, TRP channels are formed of four pore-forming subunits that assemble into the cell and function at the cell surface to control the flow of extracellular calcium across the plasma membrane. My long term objectives are to gain insight into the biological mechanisms that regulate the function of thermosensitive TRP channels. We employ multidisciplinary approaches including state of the art imaging, electrophysiology, molecular techniques to study the biogenesis and cell surface expression of these channels. We also aim to understand how environmental and endogenous factors (i.e hormones, cytokines and neurotransmitters) modulate the trafficking and the activity of these channels. The proposed project focuses on the heat sensitive TRPV1 channel also activated by capsaicin, the `hot' compound from chili peppers. As a calcium-permeant channel, TRPV1 is involved in specific calcium-dependent signalling pathways that modulate neuronal communication in sensory processing. Our proposal will identify the Ca2+-dependent processes that control TRPV1 channel assembly in the ER, trafficking to the plasma membrane and signalling to the nucleus where gene transcription is regulated. Our work will develop a framework for understanding thermosensation and sensory adaptation to noxious thermal stimuli. This project relies on considerable expertise and preliminary data that I have obtained as a postdoctoral fellow and an assistant professor at the University of Calgary. Our findings will establish a basis for new lines of research which I will use to build a strong training program in a stimulating research environment. This will create opportunities for graduate and undergraduate students and foster the development of scientific knowledge.
瞬时受体电位(TRP)通道是检测和传递物理和化学刺激的跨膜蛋白。它们参与神经系统的各种感觉功能,包括视觉、味觉、痛觉和热感觉。我的研究项目主要是TRP通道的热敏家族的分子药理学,检测热,冷和暖温度。在分子水平上,TRP通道由四个成孔亚基组成,这些亚基聚集在细胞内,在细胞表面起作用,控制细胞外钙在质膜上的流动。我的长期目标是深入了解调节热敏TRP通道功能的生物学机制。我们采用多学科方法,包括最先进的成像,电生理学,分子技术来研究这些通道的生物发生和细胞表面表达。我们还旨在了解环境和内源性因素(即激素,细胞因子和神经递质)如何调节这些通道的贩运和活动。这个项目的重点是热敏TRPV1通道,它也被辣椒素激活,辣椒素是一种来自辣椒的“辣”化合物。作为钙渗透通道,TRPV1参与调节感觉加工中神经元通讯的特定钙依赖信号通路。我们的建议将确定Ca2+依赖的过程,控制内质网中TRPV1通道的组装,运输到质膜和信号传导到细胞核,基因转录被调节。我们的工作将为理解热感觉和对有害热刺激的感觉适应建立一个框架。这个项目依赖于我在卡尔加里大学担任博士后和助理教授期间获得的大量专业知识和初步数据。我们的研究结果将为新的研究领域奠定基础,我将利用这些研究成果在一个令人兴奋的研究环境中建立一个强有力的培训计划。这将为研究生和本科生创造机会,并促进科学知识的发展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Altier, Christophe其他文献
Targeting the Transient Receptor Potential Vanilloid Type 1 (TRPV1) Assembly Domain Attenuates Inflammation-induced Hypersensitivity
- DOI:
10.1074/jbc.m114.558668 - 发表时间:
2014-06-13 - 期刊:
- 影响因子:4.8
- 作者:
Flynn, Robyn;Chapman, Kevin;Altier, Christophe - 通讯作者:
Altier, Christophe
Prion protein attenuates excitotoxicity by inhibiting NMDA receptors.
prion蛋白通过抑制NMDA受体减轻兴奋性毒性。
- DOI:
10.1083/jcb.200711002 - 发表时间:
2008-05-05 - 期刊:
- 影响因子:7.8
- 作者:
Khosravani, Houman;Zhang, Yunfeng;Tsutsui, Shigeki;Hameed, Shahid;Altier, Christophe;Hamid, Jawed;Chen, Lina;Villemaire, Michelle;Ali, Zenobia;Jirik, Frank R.;Zamponi, Gerald W. - 通讯作者:
Zamponi, Gerald W.
AKAP79 modulation of L-type channels involves disruption of intramolecular interactions in the Cav1.2 subunit
- DOI:
10.4161/chan.20865 - 发表时间:
2012-05-01 - 期刊:
- 影响因子:3.3
- 作者:
Altier, Christophe;Dubel, Stefan J.;Bourinet, Emmanuel - 通讯作者:
Bourinet, Emmanuel
Spinal A(3) adenosine receptor activation acutely restores morphine antinociception in opioid tolerant male rats.
- DOI:
10.1002/jnr.24869 - 发表时间:
2022-01 - 期刊:
- 影响因子:4.2
- 作者:
Leduc-Pessah, Heather;Xu, Cynthia;Fan, Churmy Y.;Dalgarno, Rebecca;Kohro, Yuta;Sparanese, Sydney;Burke, Nikita N.;Jacobson, Kenneth A.;Altier, Christophe;Salvemini, Daniela;Trang, Tuan - 通讯作者:
Trang, Tuan
Signaling complexes of voltage-gated calcium channels and G protein-coupled receptors
- DOI:
10.1080/10799890801941947 - 发表时间:
2008-01-01 - 期刊:
- 影响因子:2.8
- 作者:
Altier, Christophe;Zamponi, Gerald W. - 通讯作者:
Zamponi, Gerald W.
Altier, Christophe的其他文献
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{{ truncateString('Altier, Christophe', 18)}}的其他基金
Mechanistic understanding of the thermosensitive Transient Receptor Potential (TRP) channels.
对热敏瞬时受体电位 (TRP) 通道的机制了解。
- 批准号:
RGPIN-2015-06715 - 财政年份:2019
- 资助金额:
$ 2.19万 - 项目类别:
Discovery Grants Program - Individual
Mechanistic understanding of the thermosensitive Transient Receptor Potential (TRP) channels.
对热敏瞬时受体电位 (TRP) 通道的机制了解。
- 批准号:
RGPIN-2015-06715 - 财政年份:2017
- 资助金额:
$ 2.19万 - 项目类别:
Discovery Grants Program - Individual
Mechanistic understanding of the thermosensitive Transient Receptor Potential (TRP) channels.
对热敏瞬时受体电位 (TRP) 通道的机制了解。
- 批准号:
RGPIN-2015-06715 - 财政年份:2016
- 资助金额:
$ 2.19万 - 项目类别:
Discovery Grants Program - Individual
Mechanistic understanding of the thermosensitive Transient Receptor Potential (TRP) channels.
对热敏瞬时受体电位 (TRP) 通道的机制了解。
- 批准号:
RGPIN-2015-06715 - 财政年份:2015
- 资助金额:
$ 2.19万 - 项目类别:
Discovery Grants Program - Individual
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