Characterization of docosahexaenoic acid brain uptake and metabolism after consumption of different dietary forms

食用不同饮食形式后二十二碳六烯酸大脑摄取和代谢的特征

基本信息

  • 批准号:
    515272-2017
  • 负责人:
  • 金额:
    $ 9.23万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Collaborative Research and Development Grants
  • 财政年份:
    2018
  • 资助国家:
    加拿大
  • 起止时间:
    2018-01-01 至 2019-12-31
  • 项目状态:
    已结题

项目摘要

Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid that is highly enriched in the brain. DHA plays a crucial role in brain development, neuronal survival, and it can't be synthesized from scratch by our body. It is recommended to consume DHA in the diet where it is almost exclusively found in fish. However, there is not enough DHA available from fish stocks to meet global dietary recommendations. DHA can be consumed in two main dietary forms: phospholipids or triglycerides. Some studies suggest that DHA as a phospholipid would be more efficient for enriching the brain than DHA as a triglyceride. However, there are different types of phospholipids and they might not all be equal in terms of absorption and transport to the brain. Therefore, using rat and mouse models, our objective is to compare different forms of phospholipid DHA on the basis of their efficiency to enrich the brain with DHA. Rats will ingest different forms of DHA tracers, either acutely or chronically, and brain enrichment will be assessed. In subsequent studies, we will feed the selected DHA phospholipids as supplements to adult or developing mice and characterize the differences in brain metabolism between the DHA forms. The results of these studies will help us characterize which form of DHA is the best, per dose, to enrich the brain. By answering this question, we will contribute to a better understanding of the basic mechanisms that regulate DHA metabolism.******
二十二碳六烯酸(DHA)是一种ω-3多不饱和脂肪酸,在大脑中高度富集。DHA在大脑发育和神经元存活中起着至关重要的作用,它不能由我们的身体从头开始合成。建议在饮食中摄入DHA,因为它几乎只存在于鱼类中。然而,从鱼类中获得的DHA不足以满足全球饮食建议。DHA可以以两种主要饮食形式摄入:磷脂或甘油三酯。一些研究表明,DHA作为磷脂比DHA作为甘油三酯更有效地丰富大脑。然而,有不同类型的磷脂,它们在吸收和运输到大脑方面可能并不相同。因此,使用大鼠和小鼠模型,我们的目的是比较不同形式的磷脂DHA对大脑富集DHA的效率。大鼠将急性或慢性摄入不同形式的DHA示踪剂,并评估大脑富集情况。在随后的研究中,我们将选择DHA磷脂作为补充剂喂养成年或发育中的小鼠,并表征DHA形式之间的脑代谢差异。这些研究的结果将帮助我们确定哪种形式的DHA是最好的,每剂量,以丰富大脑。通过回答这个问题,我们将有助于更好地了解调节DHA代谢的基本机制。

项目成果

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Bazinet, Richard其他文献

Bazinet, Richard的其他文献

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{{ truncateString('Bazinet, Richard', 18)}}的其他基金

Discovery and characterization of signaling molecules from tetracosahexaenoic acid
二十四碳六烯酸信号分子的发现和表征
  • 批准号:
    RGPIN-2017-06465
  • 财政年份:
    2021
  • 资助金额:
    $ 9.23万
  • 项目类别:
    Discovery Grants Program - Individual
A novel isotope ratio mass spectrometry method for the characterization of the effects of linoleic acid intake on DHA synthesis and turnover rates
一种新的同位素比质谱方法,用于表征亚油酸摄入量对 DHA 合成和周转率的影响
  • 批准号:
    567561-2021
  • 财政年份:
    2021
  • 资助金额:
    $ 9.23万
  • 项目类别:
    Alliance Grants
Characterization of docosahexaenoic acid brain uptake and metabolism after consumption of different dietary forms
食用不同饮食形式后二十二碳六烯酸大脑摄取和代谢的特征
  • 批准号:
    515272-2017
  • 财政年份:
    2020
  • 资助金额:
    $ 9.23万
  • 项目类别:
    Collaborative Research and Development Grants
Discovery and characterization of signaling molecules from tetracosahexaenoic acid
二十四碳六烯酸信号分子的发现和表征
  • 批准号:
    RGPIN-2017-06465
  • 财政年份:
    2020
  • 资助金额:
    $ 9.23万
  • 项目类别:
    Discovery Grants Program - Individual
Discovery and characterization of signaling molecules from tetracosahexaenoic acid
二十四碳六烯酸信号分子的发现和表征
  • 批准号:
    RGPIN-2017-06465
  • 财政年份:
    2019
  • 资助金额:
    $ 9.23万
  • 项目类别:
    Discovery Grants Program - Individual
Discovery and characterization of signaling molecules from tetracosahexaenoic acid
二十四碳六烯酸信号分子的发现和表征
  • 批准号:
    RGPIN-2017-06465
  • 财政年份:
    2018
  • 资助金额:
    $ 9.23万
  • 项目类别:
    Discovery Grants Program - Individual
Discovery and characterization of signaling molecules from tetracosahexaenoic acid
二十四碳六烯酸信号分子的发现和表征
  • 批准号:
    RGPIN-2017-06465
  • 财政年份:
    2017
  • 资助金额:
    $ 9.23万
  • 项目类别:
    Discovery Grants Program - Individual
New models to measure the synthesis of docosahexaenoic acid from dietary alpha-linolenic acid: relevance for brain homeostasis
测量膳食α-亚麻酸中二十二碳六烯酸合成的新模型:与大脑稳态的相关性
  • 批准号:
    461776-2013
  • 财政年份:
    2015
  • 资助金额:
    $ 9.23万
  • 项目类别:
    Collaborative Research and Development Grants
Mechanisms involved in maintaining brain fatty acid concentrations: Uptake and metabolism.
维持脑脂肪酸浓度的机制:摄取和代谢。
  • 批准号:
    341416-2012
  • 财政年份:
    2015
  • 资助金额:
    $ 9.23万
  • 项目类别:
    Discovery Grants Program - Individual
New models to measure the synthesis of docosahexaenoic acid from dietary alpha-linolenic acid: relevance for brain homeostasis
测量膳食α-亚麻酸中二十二碳六烯酸合成的新模型:与大脑稳态的相关性
  • 批准号:
    461776-2013
  • 财政年份:
    2014
  • 资助金额:
    $ 9.23万
  • 项目类别:
    Collaborative Research and Development Grants

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