New models to measure the synthesis of docosahexaenoic acid from dietary alpha-linolenic acid: relevance for brain homeostasis

测量膳食α-亚麻酸中二十二碳六烯酸合成的新模型：与大脑稳态的相关性

• 批准号: 461776-2013
• 负责人: Bazinet, Richard
• 金额: $ 3.59万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=556435
• 关键词: New; models; measure; synthesis; docosahexaenoic

The brain requires an omega-3 fatty acid called DHA to maintain normal brain function. We can supply the brain with DHA from fish, however there is much concern about the sustainability of Canadian and global fish stocks. We can also consume an omega-3 fatty acid from plants and convert it to DHA in our liver. Whether or not the amount of DHA we can make from plant omega-3 is enough for the brain is not known. Our studies will define what percentage of brain DHA we can get from plant omega-3. We are going to compare new methods to measure the synthesis of DHA with methods used in humans and gold standard methods. Canada is a major producer of plant sources of omega-3 (canola, soybean and flax). These sustainable, renewable plant sources of omega-3 may be sufficient to maintain normal brain function.

大脑需要一种名为DHA的omega-3脂肪酸来维持正常的大脑功能。我们可以从鱼中为大脑提供DHA，但人们对加拿大和全球鱼类资源的可持续性有很大的担忧。我们也可以从植物中摄取一种omega-3脂肪酸，并在我们的肝脏中将其转化为DHA。我们从植物omega-3中提取的DHA含量是否足够用于大脑尚不清楚。我们的研究将确定我们可以从植物omega-3中获得多大比例的大脑DHA。我们将把测量DHA合成的新方法与人类使用的方法和金标准方法进行比较。加拿大是omega-3(油菜籽、大豆和亚麻)植物来源的主要生产国。这些可持续、可再生的植物来源的omega-3可能足以维持正常的大脑功能。