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SIGIRR: Preserving Gut Defense by Suppressing Epithelial TLR/IL-1R Signaling

SIGIRR: Preserving Gut Defense by Suppressing Epithelial TLR/IL-1R Signaling
SIGIRR:通过抑制上皮 TLR/IL-1R 信号传导来保护肠道防御
批准号:
380169
负责人:
Vallance Bruce A
金额:
$72.45万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2018
资助国家:
加拿大
项目状态:
已结题
起止时间:
2018-03-01 至 2023-03-01

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中文摘要
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英文摘要
The human gut is normally filled with 'good' bacteria that help us digest our food. They also help defend us from 'bad' bacteria that cause food poisoning. It is important that our immune system does not attack these 'good' bacteria, since this would lead
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Colonic mucus-derived sugars fuel the growth and virulence of pathogenic enteric bacteria.
  • 批准号:
    478324
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    Operating Grants
  • 资助金额:
    $69.66万
  • 财政年份:
    2023
  • 负责人:
    Vallance Bruce A
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Colonic Goblet Cells and Mucus: Defining Their Roles in Host Defense and Mucosal Protection
  • 批准号:
    443607
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  • 资助金额:
    $66.88万
  • 财政年份:
    2021
  • 负责人:
    Vallance Bruce A
  • 依托单位:
Role of microbes in the pathogenesis of PIBD: From discovery, through causation, to novel treatments
  • 批准号:
    417360
  • 项目类别:
    Operating Grants
  • 资助金额:
    $145.7万
  • 财政年份:
    2019
  • 负责人:
    Vallance Bruce A
  • 依托单位:
Role of microbes in the pathogenesis of PIBD: From discovery, through causation, to novel treatments
  • 批准号:
    399166
  • 项目类别:
    Operating Grants
  • 资助金额:
    $1.82万
  • 财政年份:
    2018
  • 负责人:
    Vallance Bruce A
  • 依托单位:
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