Integrated biosensors

集成生物传感器

基本信息

  • 批准号:
    508305-2016
  • 负责人:
  • 金额:
    $ 6.56万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Collaborative Research and Development Grants
  • 财政年份:
    2018
  • 资助国家:
    加拿大
  • 起止时间:
    2018-01-01 至 2019-12-31
  • 项目状态:
    已结题

项目摘要

This project aims to advance an optical biosensor platform. This objective will be met, initially through the design and modelling of concepts for a benchtop interrogator and for biosensor chips, then through implementation of the interrogator using commercially-available components, custom-machined parts, and software designed and written for interrogator control, data acquisition and processing, and of the biosensor chips by applying wafer-scale microfabrication processes using standard semiconductor fabrication tools in a cleanroom setting. Operation of the interrogator and biosensor chips will be demonstrated by application to biodetection problems relevant to drug discovery and point-of-care diagnostics, initially in clean fluids, then in complex fluids. Protocols for direct detection, sandwich assays, competitive assays, and kinetics extraction will be developed for application to biomolecular interaction analysis (BIA). Protocols for the detection of diseases, such as heart disease and thyroid deficiency, will be developed, based on the detection of soluble biomarkers in patient blood samples (serum, plasma). Upon completion of the project, the outcomes, consisting of the benchtop interrogator, biosensor chips, detection protocols, and biodetection results will be transferred to Canadian industry. The benefits to Canadian industry include the provision of a new high-performance benchtop biodetection platform in demonstrator form, suitable to drug discovery and disease detection applications. The biodetection protocols and results validating the platform, will be disseminated to the scientific community, particularly within the biosensors discipline. The HQP formed through this project will develop skills that are highly valued within industry and academia. They will interact with the industrial partner over the duration of the project and ultimately participate in technology transfer to industry.
该项目旨在推进光学生物传感器平台。这一目标将得到满足,首先通过台式传感器和生物传感器芯片的概念设计和建模,然后通过使用商业可用组件,定制加工部件和为传感器控制,数据采集和处理设计和编写的软件来实现传感器,以及通过在洁净室环境中使用标准半导体制造工具应用晶片级微制造工艺来制造生物传感器芯片。操作的生物传感器和生物传感器芯片将被证明通过应用到生物检测问题相关的药物发现和即时诊断,最初在清洁的流体,然后在复杂的流体。将开发用于生物分子相互作用分析(BIA)的直接检测、夹心测定、竞争测定和动力学提取的方案。将在检测患者血液样本(血清、血浆)中可溶性生物标志物的基础上,制定心脏病和甲状腺缺陷等疾病的检测方案。项目完成后,包括台式生物传感器、生物传感器芯片、检测协议和生物检测结果在内的成果将转移到加拿大工业界。对加拿大工业的好处包括提供一个新的高性能台式生物检测平台,以示范形式,适用于药物发现和疾病检测应用。生物检测协议和验证平台的结果将分发给科学界,特别是生物传感器学科。通过该项目形成的HQP将开发在行业和学术界高度重视的技能。他们将在项目期间与工业伙伴互动,并最终参与向工业界的技术转让。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Berini, Pierre其他文献

High-responsivity sub-bandgap hot-hole plasmonic Schottky detectors
  • DOI:
    10.1364/oe.24.022544
  • 发表时间:
    2016-10-03
  • 期刊:
  • 影响因子:
    3.8
  • 作者:
    Alavirad, Mohammad;Olivieri, Anthony;Berini, Pierre
  • 通讯作者:
    Berini, Pierre
Serological Diagnosis of Dengue Infection in Blood Plasma Using Long-Range Surface Plasmon Waveguides
  • DOI:
    10.1021/ac403539k
  • 发表时间:
    2014-02-04
  • 期刊:
  • 影响因子:
    7.4
  • 作者:
    Wong, Wei Ru;Krupin, Oleksiy;Berini, Pierre
  • 通讯作者:
    Berini, Pierre
Polaritonic frequency-comb generation and breather propagation in a negative-index metamaterial with a cold four-level atomic medium
  • DOI:
    10.1103/physreva.99.051802
  • 发表时间:
    2019-05-10
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Asgarnezhad-Zorgabad, Saeid;Berini, Pierre;Sanders, Barry C.
  • 通讯作者:
    Sanders, Barry C.
Tunable Plasmonic Metasurfaces for Optical Phased Arrays
Biosensing using straight long-range surface plasmon waveguides
  • DOI:
    10.1364/oe.21.000698
  • 发表时间:
    2013-01-14
  • 期刊:
  • 影响因子:
    3.8
  • 作者:
    Krupin, Oleksiy;Asiri, Hamoudi;Berini, Pierre
  • 通讯作者:
    Berini, Pierre

Berini, Pierre的其他文献

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{{ truncateString('Berini, Pierre', 18)}}的其他基金

Foundational and Applied Surface Plasmon Photonics
基础和应用表面等离子体光子学
  • 批准号:
    RGPIN-2021-03314
  • 财政年份:
    2022
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Discovery Grants Program - Individual
Foundational and Applied Surface Plasmon Photonics
基础和应用表面等离子体光子学
  • 批准号:
    RGPIN-2021-03314
  • 财政年份:
    2021
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Discovery Grants Program - Individual
Optical phased array based on electrically tunable plasmonic nanoantennas
基于电可调等离子体纳米天线的光学相控阵
  • 批准号:
    533970-2018
  • 财政年份:
    2020
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Collaborative Research and Development Grants
Surface plasmon photonics: from fundamentals to applications
表面等离子体光子学:从基础到应用
  • 批准号:
    RGPIN-2016-04197
  • 财政年份:
    2020
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Discovery Grants Program - Individual
Surface plasmon photonics: from fundamentals to applications
表面等离子体光子学:从基础到应用
  • 批准号:
    RGPIN-2016-04197
  • 财政年份:
    2019
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Discovery Grants Program - Individual
Optical phased array based on electrically tunable plasmonic nanoantennas
基于电可调等离子体纳米天线的光学相控阵
  • 批准号:
    533970-2018
  • 财政年份:
    2019
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Collaborative Research and Development Grants
Nano-patterning and visualization engine for a focused ion beam system
用于聚焦离子束系统的纳米图案和可视化引擎
  • 批准号:
    RTI-2019-00873
  • 财政年份:
    2018
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Research Tools and Instruments
Surface plasmon photonics: from fundamentals to applications
表面等离子体光子学:从基础到应用
  • 批准号:
    RGPIN-2016-04197
  • 财政年份:
    2018
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Discovery Grants Program - Individual
Active metasurfaces for spatial light modulation
用于空间光调制的主动超表面
  • 批准号:
    522249-2018
  • 财政年份:
    2018
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Engage Grants Program
Optical phased array based on electrically tunable plasmonic nanoantennas************
基于电可调等离子体纳米天线的光学相控阵************
  • 批准号:
    533970-2018
  • 财政年份:
    2018
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Collaborative Research and Development Grants

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Integrated multiplexed optical biosensors for rapid diagnostics
用于快速诊断的集成多重光学生物传感器
  • 批准号:
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  • 财政年份:
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  • 财政年份:
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Integrated multiplexed optical biosensors for rapid diagnostics
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    $ 6.56万
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用于时域测量的集成光子生物传感器
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集成生物传感器
  • 批准号:
    508305-2016
  • 财政年份:
    2017
  • 资助金额:
    $ 6.56万
  • 项目类别:
    Collaborative Research and Development Grants
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  • 资助金额:
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