Integrated biosensors

该项目旨在推进光学生物传感器平台。这一目标将得到满足，首先通过台式传感器和生物传感器芯片的概念设计和建模，然后通过使用商业可用组件，定制加工部件和为传感器控制，数据采集和处理设计和编写的软件来实现传感器，以及通过在洁净室环境中使用标准半导体制造工具应用晶片级微制造工艺来制造生物传感器芯片。操作的生物传感器和生物传感器芯片将被证明通过应用到生物检测问题相关的药物发现和即时诊断，最初在清洁的流体，然后在复杂的流体。将开发用于生物分子相互作用分析（BIA）的直接检测、夹心测定、竞争测定和动力学提取的方案。将在检测患者血液样本（血清、血浆）中可溶性生物标志物的基础上，制定心脏病和甲状腺缺陷等疾病的检测方案。项目完成后，包括台式生物传感器、生物传感器芯片、检测协议和生物检测结果在内的成果将转移到加拿大工业界。对加拿大工业的好处包括提供一个新的高性能台式生物检测平台，以示范形式，适用于药物发现和疾病检测应用。生物检测协议和验证平台的结果将分发给科学界，特别是生物传感器学科。通过该项目形成的HQP将开发在行业和学术界高度重视的技能。他们将在项目期间与工业伙伴互动，并最终参与向工业界的技术转让。

This project aims to advance an optical biosensor platform. This objective will be met, initially through the design and modelling of concepts for a benchtop interrogator and for biosensor chips, then through implementation of the interrogator using commercially-available components, custom-machined parts, and software designed and written for interrogator control, data acquisition and processing, and of the biosensor chips by applying wafer-scale microfabrication processes using standard semiconductor fabrication tools in a cleanroom setting. Operation of the interrogator and biosensor chips will be demonstrated by application to biodetection problems relevant to drug discovery and point-of-care diagnostics, initially in clean fluids, then in complex fluids. Protocols for direct detection, sandwich assays, competitive assays, and kinetics extraction will be developed for application to biomolecular interaction analysis (BIA). Protocols for the detection of diseases, such as heart disease and thyroid deficiency, will be developed, based on the detection of soluble biomarkers in patient blood samples (serum, plasma). Upon completion of the project, the outcomes, consisting of the benchtop interrogator, biosensor chips, detection protocols, and biodetection results will be transferred to Canadian industry. The benefits to Canadian industry include the provision of a new high-performance benchtop biodetection platform in demonstrator form, suitable to drug discovery and disease detection applications. The biodetection protocols and results validating the platform, will be disseminated to the scientific community, particularly within the biosensors discipline. The HQP formed through this project will develop skills that are highly valued within industry and academia. They will interact with the industrial partner over the duration of the project and ultimately participate in technology transfer to industry.