The anti-Helicobacter pylori properties and mechanism of action of probiotic Lactobacilli secretomes

幽门螺杆菌(Hp)是一种导致全球65%的胃溃疡和癌症的细菌。目前的抗幽门螺杆菌治疗经常失败，因为细菌已经产生抗药性，而且它们有严重的副作用。我们正在**研究使用被称为乳杆菌的细菌产生的分子来治疗和/或预防幽门螺杆菌感染。乳杆菌是人类胃肠道菌群的天然成分。我们方法的新颖性是**专注于乳杆菌释放的分子(即他们的分泌物)，这些分子可以**以受控和可靠的方式给患者使用。使用释放的分子也有助于确定**作用的机制。我们比较了25株乳杆菌产生的分泌物抗幽门螺杆菌的作用，并**鉴定出非常有活性的菌株。我们建议确定它们的作用机制，并确定**活性分子的性质。这将允许开发可用于治疗**患者或预防感染的有效配方。

Helicobacter pylori (HP) is a bacterium that causes 65% of gastric ulcers and cancers worldwide. Current anti**HP treatments often fail because the bacteria have become resistant and they have serious side effects. We are**looking into using molecules produced by bacteria called Lactobacilli that are a natural component of the**human gastro-intestinal flora to treat and/or prevent Helicobacter infections. The novelty of our approach is to**focus on the molecules that Lactobacilli release (i.e. their secretions) and that could be administered to patients**in a controlled and reliable manner. Using the released molecules also facilitates determining the mechanism of**action. We have compares the secretions produced by 25 Lactobacilli for their anti-HP effects and have**identified very active strains. We propose to determine their mechanisms of action and identify the nature of**the active molecules. This will allow the development of effective formulations that could be used to treat**patients or prevent infections.