The anti-Helicobacter pylori properties and mechanism of action of probiotic Lactobacilli secretomes

益生菌分泌乳杆菌的抗幽门螺杆菌特性和作用机制

• 批准号: 536714-2018
• 负责人: Creuzenet, Carole
• 金额: $ 0.91万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=648296
• 关键词: anti; Helicobacter; pylori; properties; mechanism

Helicobacter pylori (HP) is a bacterium that causes 65% of gastric ulcers and cancers worldwide. Current anti**HP treatments often fail because the bacteria have become resistant and they have serious side effects. We are**looking into using molecules produced by bacteria called Lactobacilli that are a natural component of the**human gastro-intestinal flora to treat and/or prevent Helicobacter infections. The novelty of our approach is to**focus on the molecules that Lactobacilli release (i.e. their secretions) and that could be administered to patients**in a controlled and reliable manner. Using the released molecules also facilitates determining the mechanism of**action. We have compares the secretions produced by 25 Lactobacilli for their anti-HP effects and have**identified very active strains. We propose to determine their mechanisms of action and identify the nature of**the active molecules. This will allow the development of effective formulations that could be used to treat**patients or prevent infections.

幽门螺杆菌（HP）是一种导致65%的胃溃疡和癌症的细菌。目前的抗HP治疗经常失败，因为细菌已经产生耐药性，并且有严重的副作用。我们正在研究使用一种叫做乳酸杆菌的细菌产生的分子来治疗和/或预防幽门螺杆菌感染。乳酸杆菌是人类胃肠道菌群的一种天然成分。我们方法的新颖之处在于专注于乳酸杆菌释放的分子（即它们的分泌物），并且可以以可控和可靠的方式给患者**。利用释放的分子也有助于确定**的作用机制。我们比较了25种乳酸菌产生的分泌物的抗hp作用，并鉴定出非常活跃的菌株。我们建议确定它们的作用机制，并确定活性分子的性质。这将允许开发有效的配方，可用于治疗**患者或预防感染。