NSERC CREATE Collaborative Medicinal Chemistry Network in Epigenetics Training (ChemNET):Training Canadian chemists within a global open access public-private partnership

拟议的CREATE项目（药物化学网络表观遗传学培训；ChemNET）将在一个开放获取的国际研究合作项目中培训下一代药物化学家，该项目涉及四所加拿大大学、结构基因组学联盟（SGC）——一个总部设在多伦多大学的非营利研究组织，以及辉瑞、诺华和葛兰素史克的国际研究实验室。这些受训者将产生研究工具来研究表观遗传学科学，这是一种影响癌症、抑郁症和糖尿病等疾病的基本基因调控机制，以及生物能源、畜牧科学和农业。作为世界领先的开放获取科学运动的一部分，生成的化学工具将不受使用限制地提供给所有研究人员。****ChemNET学员将在加拿大各地的大学接受培训，但也将在制药公司的国际实验室——药物化学的全球热点——度过时间。这个行业实习是至关重要的，因为药物化学是一门最好在“工作”中学习的学科。ChemNET还将在多伦多大学（University of Toronto）的SGC进行为期两个月的“训练营”，作为化学培训的补充。受训人员除了参加表观遗传学入门课程外，还将学习用于药物设计的专门生化和生物物理技术。一年一度的研究研讨会将为学员提供机会，展示他们的工作和网络与学术和全球行业领袖的药物化学。一个特别的在线研讨会课程将邀请一系列演讲者与受训者就与其培训相关的主题进行公开讨论。ChemNET的最终目标是通过发展他们的技术和理论知识以及他们的沟通，协作和组织能力，为学术界，工业界或政府监管部门培养高素质的药物化学家。这些科学家将领导加拿大未来在制药、农业和生物能源领域的表观遗传学工作。****

The proposed CREATE program (Medicinal Chemistry Network in Epigenetics Training; ChemNET) will**train the next generation of medicinal chemists within an open access, international research collaboration involving four Canadian universities, the Structural Genomics Consortium (SGC) - a not-for-profit research organization based at the University of Toronto, and the international research labs of Pfizer, Novartis and GSK. The trainees will generate research tools to study the science of epigenetics, a fundamental gene regulatory mechanism that influences diseases such as cancer, depression and diabetes, as well as bioenergy, livestock science and agriculture. The chemical tools generated will be made available to all researchers without restriction on use, as part of a world-leading movement in open access science.****ChemNET trainees will train in universities across Canada, but will also spend time in the international labs of the pharmaceutical companies- the global hotspots for medicinal chemistry. This industry internship is critical because medicinal chemistry is a discipline best learned "on the job". ChemNET will also complement the chemistry training with a two-months "Bootcamp" at the SGC at the University of Toronto, where the trainees will learn specialized biochemical and biophysical techniques for drug design, in addition to enrolling in a primer course on epigenetics. An Annual Research Symposium will provide the trainees with the opportunity to present their work and network with academic and global industry leaders of medicinal chemistry. A special online seminar course will invite a range of speakers for an open discussion with the trainees on topics of relevance to their training. ChemNET's ultimate objective is to train highly-qualified medicinal chemists for academia, industry or the regulatory divisions of government by developing their technical and theoretical knowledge as well as their communication, collaborative and organizational skills. These scientists will lead Canada's future epigenetics efforts within the pharmaceutical, agriculture and bioenergy sectors.****