Ligand Designs for Catalysis: New Directions for Green Chemistry

在绿色化学这一创新的研究计划将在该领域产生很大的影响，并将在化学本科生，研究生和高级研究人员提供高水平的培训机会，因此是一个基本的科学学习涉及创新的高影响力的研究计划在化学（即自然）科学。我们以前设计过用于“绿色”化学的系统;例如，用于节能工艺的催化剂，以及用于制造使用当前技术难以制造或昂贵的材料的催化剂。我们通过多种方法来衡量这项工作的影响：专利技术（我们最近为专门的聚合物应用申请了新催化剂的专利），科学披露，如期刊文章（2006-2012年，我们在同行评审的科学期刊上发表了30多篇论文），其他科学家使用我们的技术并在自己的工作中引用我们的化学。这后两个方面的一个例子是我们合成的昵称为“DMU-212”的乳腺癌候选药物。我们披露了我们的一种催化剂可以用于制造这种分子，并且在几个月内，我们收到了另一个研究团队（位于AB）的请求，要求提供这种催化剂的样品和我们合成方法的细节。他们使用通过我们的方案/催化剂生产的DMU-212用于使用该药物的关键临床研究。详细描述这种催化剂的已发表论文因其对其他科学家及其工作的影响而获得了一家主要科学出版社颁发的“2004-2007年最受引用论文奖”。因此，这项建议的重点是通过开展重要的高影响力研究来培训科学家。在化学科学的培训允许一个人追求各种职业道路作为学员整体“学会运用科学推理来解决问题”。这项资助申请旨在通过三个主要重点培训这些人员：（一）合成技术（技术培训）;（二）交流（论文/公开演讲）和（三）化学知识（背景知识，知识应用）。此后，受训者可以对涉及科学或一般情况的任何问题解决练习的适当行动方针作出合理的判断。这项工作很重要，因为它扩大了我们过去的成功（见上文），但也为加拿大作为其重要组成部分的当前化学世界的关键因素提供了重大提升：（一）绿色科学倡议;（二）钳形化学的前沿工作，其中PI是一个重要角色;以及（iii）基础化学科学的新设计和展望，以促进国家、国际和工业界的合作。

This innovative research program in Green Chemistry will have a high impact in the field and will provide high level training opportunities in chemistry for undergraduates, graduate students and senior researchers and is hence a fundamental scientific learning involving an innovation high impact research program in the chemical (i.e. natural) sciences. We have previously designed systems for "greener" chemistry; for example, catalysts for energy efficient processes and to make materials that are difficult or expensive to make using current technology. We measure the impact of this work by a number of methods: patented technology (we recently applied to patent our new catalysts for specialised polymer applications), scientific disclosures such as journal article (we have over 30 publications in peer reviewed scientific journals from 2006-2012), other scientists using our technology and citing our chemistry in their own work. An example of these latter two aspects is exemplified by our synthesis of a breast cancer drug candidate nicknamed "DMU-212". We disclosed that one of our catalysts can be used to make this molecule and within a few months we had a request from another research team (based in AB) for samples of this catalyst and details of our synthetic methods. They used DMU-212 produced via our protocols/catalyst for a key clinical study using this drug. Published work detailing this same catalyst won a "Most Cited Paper 2004-2007 Award" from a major scientific publisher due to the impact it has had on other scientists and their work. Hence, this proposal is focussed on training scientists by producing important high impact research. Training in the chemical sciences allows one to pursue a variety of career paths as the trainees overall "learn to apply scientific reasoning to solve problem". This funding application is directed towards training such personnel by applying three main foci: (i) synthetic techniques (technical training); (ii) communication (dissertation/public presentation) and (iii) knowledge of chemistry (background knowledge, knowledge application). Thereafter, trainees can make sound judgements on an appropriate course of action for any problem solving exercise involving science or situations in general. This work is important because it expands on our past success (above) but also provides significant ramping up of key factors in the current chemical world of which Canada is an important part: (i) Green Science initiatives; (ii) cutting edge work on pincer chemistry of which the PI is an important player; and (iii) new designs and outlooks for fundamental chemical science to collaborate nationally, internationally and with industry.