Ligand Designs for Catalysis: New Directions for Green Chemistry

这一绿色化学创新研究计划将在该领域产生很高的影响，并将为本科生、研究生和高级研究人员提供高水平的化学培训机会，因此是一项基础科学学习，涉及化学(即自然科学)领域的创新高影响研究计划。我们以前曾设计过“更绿色”化学的系统；例如，用于节能过程的催化剂，以及制造使用当前技术制造困难或昂贵的材料。我们通过许多方法来衡量这项工作的影响：专利技术(我们最近申请了专利，我们的新型催化剂用于特种聚合物应用)，科学披露，如期刊文章(2006年至2012年，我们在同行评议的科学期刊上发表了30多篇文章)，其他使用我们技术的科学家在他们自己的工作中引用了我们的化学。后两个方面的一个例子是我们合成了一种绰号为“DMU-212”的乳腺癌候选药物。我们透露，我们的一种催化剂可以用来制造这种分子，几个月内，我们收到了另一个研究小组(总部设在AB)的要求，要求提供这种催化剂的样品和我们的合成方法的细节。他们使用通过我们的方案/催化剂生产的DMU-212进行了一项使用这种药物的关键临床研究。由于对其他科学家和他们的工作产生了影响，详细描述这种催化剂的出版作品获得了一家主要科学出版商颁发的“2004-2007年度被引用最多论文奖”。因此，这项建议的重点是通过产生重要的高影响力研究来培训科学家。化学科学方面的培训使一个人能够追求不同的职业道路，因为受训人员总体上“学会应用科学推理来解决问题”。这项资金申请旨在通过三个主要重点对这类人员进行培训：(I)合成技术(技术培训)；(Ii)交流(论文/公开陈述)和(Iii)化学知识(背景知识、知识应用)。此后，受训者可以对任何涉及科学或一般情况的问题解决练习的适当行动方案做出合理的判断。这项工作之所以重要，是因为它扩展了我们过去的成功(如上)，而且还显著提高了当前化学世界的关键因素，加拿大是其中的重要组成部分：(I)绿色科学倡议；(Ii)钳子化学方面的尖端工作，PI是其中的重要参与者；以及(Iii)基础化学科学的新设计和展望，以便在国家、国际和工业界进行合作。

This innovative research program in Green Chemistry will have a high impact in the field and will provide high level training opportunities in chemistry for undergraduates, graduate students and senior researchers and is hence a fundamental scientific learning involving an innovation high impact research program in the chemical (i.e. natural) sciences. We have previously designed systems for "greener" chemistry; for example, catalysts for energy efficient processes and to make materials that are difficult or expensive to make using current technology. We measure the impact of this work by a number of methods: patented technology (we recently applied to patent our new catalysts for specialised polymer applications), scientific disclosures such as journal article (we have over 30 publications in peer reviewed scientific journals from 2006-2012), other scientists using our technology and citing our chemistry in their own work. An example of these latter two aspects is exemplified by our synthesis of a breast cancer drug candidate nicknamed "DMU-212". We disclosed that one of our catalysts can be used to make this molecule and within a few months we had a request from another research team (based in AB) for samples of this catalyst and details of our synthetic methods. They used DMU-212 produced via our protocols/catalyst for a key clinical study using this drug. Published work detailing this same catalyst won a "Most Cited Paper 2004-2007 Award" from a major scientific publisher due to the impact it has had on other scientists and their work. Hence, this proposal is focussed on training scientists by producing important high impact research. Training in the chemical sciences allows one to pursue a variety of career paths as the trainees overall "learn to apply scientific reasoning to solve problem". This funding application is directed towards training such personnel by applying three main foci: (i) synthetic techniques (technical training); (ii) communication (dissertation/public presentation) and (iii) knowledge of chemistry (background knowledge, knowledge application). Thereafter, trainees can make sound judgements on an appropriate course of action for any problem solving exercise involving science or situations in general. This work is important because it expands on our past success (above) but also provides significant ramping up of key factors in the current chemical world of which Canada is an important part: (i) Green Science initiatives; (ii) cutting edge work on pincer chemistry of which the PI is an important player; and (iii) new designs and outlooks for fundamental chemical science to collaborate nationally, internationally and with industry.