Mechanisms of Blood Clot Adhesion and the Design of New Wet Adhesives

血凝块粘附机制及新型湿粘合剂的设计

• 批准号: RGPIN-2018-04918
• 负责人: Kastrup, Christian
• 金额: $ 3.35万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=655180
• 关键词: Mechanisms; Blood; Clot; Adhesion; Design

Blood clots are extraordinary adhesives. They adhere to surfaces underwater and under flow with a high degree of control to rapidly and effectively seal wounds. Although the cohesive properties of blood clots have been well studied, their adhesive properties have not. To this end, my research team was the first to report the adhesive strength of whole blood clots to blood vessel surfaces. Understanding how blood clots adhere to surfaces under harsh conditions will uncover new approaches to designing smart adhesives and sealants. Designing effective wet sealants is an important engineering goal, with a wide range of possible applications including in the food industry, and for creating clothing that protects from chemical and biological hazards.***Our overarching goal is to elucidate what modulates blood clot adhesion and use this knowledge to design novel adhesives and sealants.***Over the next five years, we aim to:***1) Uncover the fundamental mechanisms of blood clot adhesion.***We will work with human and animal blood to uncover the components of blood and surfaces that contribute to adhesion and allow clots to rapidly, controllably and effectively seal wounds. Specifically, we will explore how adhesion is influenced by self-propagation of blood clots, and incorporate this unique feature into our smart adhesives and sealants.***2) Purify and optimize the components of adhesion for new applications.***Once we have identified the key components of clot adhesion to natural and artificial surfaces, we will isolate and purify them and explore ways to increase their utility in industrial applications. This includes extending shelf life and expanding the range of temperatures and conditions in which adhesion can occur.***3) Design new adhesives and sealant technologies.***We will use the optimized clot adhesion components to engineer adhesives for specific industrial applications. This includes improving commercially available animal or bacteria-derived ‘food glues,' which bind meat and produce together, improve texture, and reduce production costs. Another application is to design protective combat uniforms that can self-repair rips by releasing adhesives when damaged. There is military and industrial demand for self-sealing clothing that protects operators from chemical and biological hazards while being flexible, lightweight and cost-effective.***My research team has a successful track record of patenting and commercializing new technologies, as well as expertise in coagulation and blood clot adhesion and engineering. Insights gained will have a major impact to the field of sealants and adhesives, blood coagulation, and to the food and defence industries. By extending our current collaborations with Defence Research and Development Canada, the program will provide interdisciplinary training to Biomedical Engineering graduate students in knowledge transfer to industry and government.

血液凝块是一种特殊的粘合剂。它们附着在水下和水下的表面上，具有高度的可控性，能够快速有效地封闭伤口。尽管人们已经很好地研究了血栓的粘附性，但它们的粘附性还没有得到很好的研究。为此，我的研究小组第一个报告了全血凝块与血管表面的粘连强度。了解血液凝块如何在恶劣条件下附着在表面将发现设计智能粘合剂和密封剂的新方法。设计有效的湿式密封剂是一个重要的工程目标，可能的应用范围很广，包括在食品工业中，以及制造防止化学和生物危害的服装。*我们的首要目标是阐明是什么调节血液凝块粘连，并利用这一知识设计新型粘合剂和密封剂。*在接下来的五年里，我们的目标是：*1)揭示血液凝块粘连的基本机制。*我们将与人和动物的血液合作，揭示促成粘连的血液和表面的成分，使凝块能够快速、可控和有效地封闭伤口。具体地说，我们将探索血栓自我繁殖对粘附性的影响，并将这一独特功能整合到我们的智能粘合剂和密封剂中。*2)针对新的应用提纯和优化粘附性成分。*一旦我们确定了凝块与天然和人造表面粘附性的关键成分，我们将分离和提纯它们，并探索增加其在工业应用中的用途的方法。这包括延长保质期和扩大发生粘连的温度和条件范围。*3)设计新的粘合剂和密封剂技术。*我们将使用优化的凝块粘合组件来设计特定工业应用的粘合剂。这包括改进市面上可买到的动物或细菌衍生的“食用胶”，这种“食用胶”将肉类和农产品捆绑在一起，改善质地，降低生产成本。另一个应用是设计防护性的战斗制服，这种制服可以在破损时通过释放粘合剂来自我修复撕裂。军事和工业对自密封服装的需求是这样的，这种服装在保护操作员免受化学和生物危害的同时，具有灵活性、轻量化和成本效益。*我的研究团队在新技术专利和商业化方面有着成功的记录，以及在凝血和血液凝块粘连和工程方面的专业知识。所获得的见解将对密封剂和粘合剂、血液凝固以及食品和国防工业产生重大影响。通过扩大我们目前与加拿大国防研究和发展部的合作，该项目将为生物医学工程研究生提供跨学科的培训，帮助他们将知识转移到行业和政府。