Evaluation of the ability of an anionic nutritional supplement to improve immune function in dairy cattle around calving

阴离子营养补充剂改善产犊前后奶牛免疫功能能力的评价

• 批准号: 524500-2018
• 负责人: LeBlanc, Stephen
• 金额: $ 1.8万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=656931
• 关键词: Evaluation; ability; anionic; nutritional; supplement

The dairy industry is economically the third-largest agricultural sector in Canada, with $ 6.7 B in farm receipts**from 945,000 milking cows to just under 11,000 farms and a $19.9 B contribution to national GDP in 2015.**Dairy cows have been described as metabolic athletes. One of the challenges they face is a large and sudden**drop in blood calcium levels (hypocalcemia) right after calving as lactation begins. This transient drop in**blood calcium is risk factor for numerous subsequent health disorders. Recent research highlights that calcium**is one important element in immune function, which is known also to be compromised in the weeks around**calving, and also contributes to the risk of infectious disease at that time. Here, we propose research to explore**the ability of a commercially-available nutritional supplement which helps to prevent hypocalcemia to improve**immune function. We will undertake a controlled experiment in 26 cows from commercial farms fed either an**anionic dietary supplement or a placebo for a preliminary assessment of the effect of this technology on innate**immune function. Specifically, we will assess the effect of the treatment on the functional capacity of**neutrophils (the main cells responsible for the first line of immune defence in the uterus and the udder) to**perform phagocytosis (engulfing bacteria or damaged tissue) and oxidative burst (digestion of engulfed**bacteria). This effect, if established, has the potential to improve the health and well-being of dairy cows, and**to increase adoption of this type of nutritional approach, which currently has only moderate implementation on**Canadian dairy farms.

乳制品行业是加拿大第三大农业经济部门，2015年农场收入为67亿B美元 **，从94.5万头奶牛到不到1.1万个农场，对国家GDP的贡献为199亿B美元。奶牛被描述为代谢运动员。他们面临的挑战之一是在产犊后哺乳期开始时，血钙水平突然大幅下降（低钙血症）。这种血钙的短暂下降是许多随后的健康障碍的危险因素。最近的研究强调，钙 ** 是免疫功能的一个重要元素，已知免疫功能在产犊前后的几周内也会受到损害，并且也会增加当时感染疾病的风险。在这里，我们建议进行研究，以探索 ** 市售营养补充剂的能力，这有助于预防低钙血症，以提高 ** 免疫功能。我们将在来自商业农场的26头奶牛中进行对照实验，饲喂阴离子膳食补充剂或安慰剂，以初步评估该技术对先天免疫功能的影响。具体而言，我们将评估治疗对 ** 中性粒细胞（子宫和乳房中负责第一道免疫防御的主要细胞）进行吞噬（吞噬细菌或受损组织）和氧化爆发（消化吞噬的 ** 细菌）的功能能力的影响。这种效果，如果建立，有可能改善奶牛的健康和福祉，并增加采用这种类型的营养方法，目前只有适度的实施在 ** 加拿大奶牛场。