Understanding and Development of New Materials for High Performance Liquid Chromatography and Electrophoresis
高效液相色谱和电泳新材料的认识和开发
基本信息
- 批准号:RGPIN-2015-05763
- 负责人:
- 金额:$ 5.39万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
My research group is active in analytical separations. High performance liquid chromatography (HPLC) is ubiquitous in chemistry, biochemistry, and industrial labs. Recent years have seen many innovations in the field of HPLC - ultrahigh performance LC, core-shell phases, and hydrophilic interaction chromatography to name but a few.***The approach my group takes is to develop a fundamental physico-chemical understanding of the methodology. We then use that understanding to enhance and empower the analytical methods.****Within this broad programmatic objective, the short term objective of this DG proposal is to develop and investigate novel polar surfaces for hydrophilic interaction liquid chromatography, normal phase liquid chromatography, and capillary electrophoresis, and to introduce polar modification to porous graphitic carbon to attenuate its strong reversed phase adsorption.****Porous graphitic carbon is an attractive phase for HPLC due to its chemical stability and unique selectivity. Building on our past success, we will introduce polar functionalities including amide, catechol, saccharide and poly(oxyethylene) to the carbon surface using diazonium chemistry. This polar modification will enhance multiple modes of HPLC separation. In the ubiquitous reversed-phase liquid chromatography, our polar modifications will attenuate the excessive retention and peak tailing that limits the use of carbon HPLC particles. Hydrophilic interaction liquid chromatography is a rapidly growing mode of HPLC, but one that is restricted to pH 2-8 and We will also investigate the facile modification of porous carbon HPLC particles using pi-pi adsorptive strategies that are popular for modification of carbon nanomaterials. Preliminary results with non-ionic surfactants on carbon indicate that the modification is robust under a range of solvents.***Development of polar hydrophilic coatings for capillary electrophoresis will complement our studies of polar chromatographic phases, and provide training opportunities in a diversity of analytical separation methodologies.****The above work will be interwoven with fundamental studies of the nature of polar interactions in liquid chromatography. We investigate the impact of: non-traditional solvents on hydrophilic interaction liquid chromatography; temperature on retention and selectivity; and localization of polar interactions in normal phase chromatography.**
我的研究小组在分析分离方面很活跃。 高效液相色谱(HPLC)在化学、生物化学和工业实验室中无处不在。近年来,在HPLC领域出现了许多创新-高性能LC、核-壳相和亲水相互作用色谱,仅举几例。*我的小组采取的方法是发展对方法的基本物理化学理解。然后,我们利用这种理解来增强和授权分析方法。在这一广泛的计划目标内,本DG提案的短期目标是开发和研究用于亲水相互作用液相色谱、正相液相色谱和毛细管电泳的新型极性表面,并对多孔石墨碳进行极性改性以减弱其强反相吸附。多孔石墨碳由于其化学稳定性和独特的选择性而成为高效液相色谱的一个有吸引力的相。 在我们过去成功的基础上,我们将使用重氮化学在碳表面引入极性官能团,包括酰胺,邻苯二酚,糖和聚(氧化物)。 这种极性修饰将增强HPLC分离的多种模式。 在无处不在的反相液相色谱中,我们的极性修饰将削弱限制碳HPLC颗粒使用的过度保留和峰拖尾。 亲水相互作用液相色谱是一种快速发展的HPLC模式,但仅限于pH 2-8,我们还将研究使用π-π吸附策略对多孔碳HPLC颗粒的简易修饰,该策略在碳纳米材料的修饰中很受欢迎。碳上的非离子表面活性剂的初步结果表明,该改性在一系列溶剂下是稳健的。开发用于毛细管电泳的极性亲水涂层将补充我们对极性色谱相的研究,并提供多种分析分离方法的培训机会。*上述工作将与液相色谱中极性相互作用性质的基础研究交织在一起。 我们调查以下因素的影响:非传统溶剂对亲水作用液相色谱的影响;温度对保留和选择性的影响;正相色谱中极性相互作用的定位。**
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Lucy, Charles其他文献
Lucy, Charles的其他文献
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{{ truncateString('Lucy, Charles', 18)}}的其他基金
Understanding and Development of New Materials for High Performance Liquid Chromatography and Electrophoresis
高效液相色谱和电泳新材料的认识和开发
- 批准号:
RGPIN-2015-05763 - 财政年份:2019
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Understanding and Development of New Materials for High Performance Liquid Chromatography and Electrophoresis
高效液相色谱和电泳新材料的认识和开发
- 批准号:
RGPIN-2015-05763 - 财政年份:2017
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Understanding and Development of New Materials for High Performance Liquid Chromatography and Electrophoresis
高效液相色谱和电泳新材料的认识和开发
- 批准号:
RGPIN-2015-05763 - 财政年份:2016
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Understanding and Development of New Materials for High Performance Liquid Chromatography and Electrophoresis
高效液相色谱和电泳新材料的认识和开发
- 批准号:
RGPIN-2015-05763 - 财政年份:2015
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Appropriate technology in analytical separations
分析分离的适当技术
- 批准号:
138579-2007 - 财政年份:2014
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Appropriate technology in analytical separations
分析分离的适当技术
- 批准号:
138579-2007 - 财政年份:2013
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Appropriate technology in analytical separations
分析分离的适当技术
- 批准号:
138579-2007 - 财政年份:2012
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Appropriate technology in analytical separations
分析分离的适当技术
- 批准号:
138579-2007 - 财政年份:2011
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
Replacement capillary electrophoresis instrument
替换毛细管电泳仪
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406435-2011 - 财政年份:2010
- 资助金额:
$ 5.39万 - 项目类别:
Research Tools and Instruments - Category 1 (<$150,000)
Appropriate technology in analytical separations
分析分离的适当技术
- 批准号:
138579-2007 - 财政年份:2010
- 资助金额:
$ 5.39万 - 项目类别:
Discovery Grants Program - Individual
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