Time variation, nonlinearity and heterogeneity mechanics of tissues: application to the respiratory system

组织的时间变化、非线性和异质性力学:在呼吸系统中的应用

基本信息

  • 批准号:
    RGPIN-2017-06929
  • 负责人:
  • 金额:
    $ 2.84万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2018
  • 资助国家:
    加拿大
  • 起止时间:
    2018-01-01 至 2019-12-31
  • 项目状态:
    已结题

项目摘要

This program of research is to explore analytically, computationally and experimentally the impact of nonstationarity in physiological systems on the analysis of oscillatory mechanics. It also aims to develop novel microtissue based system arrays, that enable the study of mechanobiology in tissue consisting of only 200-300 cells each. ******The approach to building the microtissue arrays is to use piezoelectric based material to form actuated posts in pairs embedded in a premade silicone mould for holding the tissues. The actuators oscillate and load the tissues over a range of frequencies and amplitude. ******We will develop this actuator system for ease of use for other researchers, and also we will use it to probe the microtissue time varying mechanical properties at the cell, tissue and whole lung level to investigate a recent discovery in my lab that has broad implications for understanding soft tissue mechanics.******We recently began exploring the impact of correctly accounting for time variation of mechanical properties of the respiratory system, and discovered a heretofore unknown relationship that can predict the well-established frequency dependence of resistance of lung tissue and the respiratory mechanics. This system behavior is currently attributed to the viscoelasticity of lung tissue or to heterogeneity amongst airway diameters. As such, the prediction from analysis of time-varying mechanics opens a new area of research of soft tissue mechanics, particularly in the lung where both resistance and elastance are known to be strongly time varying during breathing, particularly with airway obstruction. The theory may have deep implications as to the coupling of elastic and dissipative forces and nonlinear recruitment-derecruitment behavior during stretch and relaxation at the level of the cell, the tissue or the airway in the lung. ******We will use experimental measurements to validate and inform our lung models. This proposal includes training in several areas, including general systems analysis, mathematical modelling applied to physiological systems, signal and systems analysis including linear, nonlinear, heterogeneous and time variant systems. It also includes training in the measurement and understanding of soft tissue mechanics and mechanical behavior with a focus on the respiratory system. ******Significance: This program of research builds on the research in lung mechanics and lung tissue mechanical properties and physiology that founded my research career. If the predictions we are making in my lab are true, this work will represent my greatest contribution to lung mechanics and indeed to understanding of the mechanical properties of time-varying physiological systems in general. It has the potential to lead to a new conceptual framework for the frequency response of mechanical systems when the underlying mechanics are not stationary.
本研究计画旨在探讨分析、计算与实验上生理系统非平稳性对振荡力学分析的影响。它还旨在开发新的基于微组织的系统阵列,使每个仅由200-300个细胞组成的组织中的机械生物学研究成为可能。****** 构建微组织阵列的方法是使用基于压电的材料来形成成对的致动柱,所述致动柱嵌入预制的用于保持组织的硅树脂模具中。致动器在一定的频率和振幅范围内振荡并加载组织。** 我们将开发这种致动器系统,以便于其他研究人员使用,我们还将使用它来探测细胞,组织和整个肺部水平的微组织时变机械特性,以研究我实验室最近的发现,该发现对理解软组织力学具有广泛的影响。我们最近开始探索正确解释呼吸系统机械特性随时间变化的影响,并发现了一种迄今为止未知的关系,可以预测肺组织阻力和呼吸力学的良好频率依赖性。这种系统行为目前归因于肺组织的粘弹性或气道直径之间的异质性。因此,从时变力学分析的预测开辟了软组织力学研究的新领域,特别是在肺中,其中已知阻力和弹性在呼吸期间是强烈时变的,特别是在气道阻塞的情况下。该理论可能对肺细胞、组织或气道水平上拉伸和松弛过程中弹性力和耗散力的耦合以及非线性招募-去招募行为具有深刻的意义。****** 我们将使用实验测量来验证和告知我们的肺部模型。该建议包括几个领域的培训,包括一般系统分析,应用于生理系统的数学建模,信号和系统分析,包括线性,非线性,异构和时变系统。它还包括测量和理解软组织力学和机械行为的培训,重点是呼吸系统。** 重要性:这个研究项目建立在肺力学和肺组织机械特性和生理学的研究基础上,这些研究奠定了我的研究生涯。如果我们在实验室所做的预测是正确的,那么这项工作将代表我对肺力学的最大贡献,实际上也是对一般时变生理系统的机械特性的理解。它有可能导致一个新的概念框架的机械系统的频率响应时,基本力学是不稳定的。

项目成果

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Maksym, Geoffrey其他文献

Early detection of changes in lung mechanics with oscillometry following bariatric surgery in severe obesity

Maksym, Geoffrey的其他文献

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{{ truncateString('Maksym, Geoffrey', 18)}}的其他基金

Time variation, nonlinearity and heterogeneity mechanics of tissues: application to the respiratory system
组织的时间变化、非线性和异质性力学:在呼吸系统中的应用
  • 批准号:
    RGPIN-2017-06929
  • 财政年份:
    2021
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Discovery Grants Program - Individual
Time variation, nonlinearity and heterogeneity mechanics of tissues: application to the respiratory system
组织的时间变化、非线性和异质性力学:在呼吸系统中的应用
  • 批准号:
    RGPIN-2017-06929
  • 财政年份:
    2020
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Discovery Grants Program - Individual
Time variation, nonlinearity and heterogeneity mechanics of tissues: application to the respiratory system
组织的时间变化、非线性和异质性力学:在呼吸系统中的应用
  • 批准号:
    RGPIN-2017-06929
  • 财政年份:
    2019
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Discovery Grants Program - Individual
Time variation, nonlinearity and heterogeneity mechanics of tissues: application to the respiratory system
组织的时间变化、非线性和异质性力学:在呼吸系统中的应用
  • 批准号:
    RGPIN-2017-06929
  • 财政年份:
    2017
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Discovery Grants Program - Individual
NSERC CREATE: bioMedic - a training program in biomedical technology innovation and commercialization
NSERC CREATE:bioMedic - 生物医学技术创新和商业化培训计划
  • 批准号:
    372600-2009
  • 财政年份:
    2014
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Collaborative Research and Training Experience
NSERC CREATE: bioMedic - a training program in biomedical technology innovation and commercialization
NSERC CREATE:bioMedic - 生物医学技术创新和商业化培训计划
  • 批准号:
    372600-2009
  • 财政年份:
    2013
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Collaborative Research and Training Experience
NSERC CREATE: bioMedic - a training program in biomedical technology innovation and commercialization
NSERC CREATE:bioMedic - 生物医学技术创新和商业化培训计划
  • 批准号:
    372600-2009
  • 财政年份:
    2012
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Collaborative Research and Training Experience
NSERC CREATE: bioMedic - a training program in biomedical technology innovation and commercialization
NSERC CREATE:bioMedic - 生物医学技术创新和商业化培训计划
  • 批准号:
    372600-2009
  • 财政年份:
    2011
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Collaborative Research and Training Experience
NSERC CREATE: bioMedic - a training program in biomedical technology innovation and commercialization
NSERC CREATE:bioMedic - 生物医学技术创新和商业化培训计划
  • 批准号:
    372600-2009
  • 财政年份:
    2010
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Collaborative Research and Training Experience
NSERC CREATE: bioMedic - a training program in biomedical technology innovation and commercialization
NSERC CREATE:bioMedic - 生物医学技术创新和商业化培训计划
  • 批准号:
    372600-2009
  • 财政年份:
    2009
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Collaborative Research and Training Experience

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