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Establishing a new class of senolytics to treat age-related pathologies and extending lifespan

Establishing a new class of senolytics to treat age-related pathologies and extending lifespan
建立一类新的 senolytics 来治疗与年龄相关的病症并延长寿命
批准号：
398880
负责人：
Mallette Frdrick A
金额：
$32.78万
依托单位：
Centre de recherche de l'Hôpital Maisonneuve-Rosemont (Montral)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2018
资助国家：
加拿大
项目状态：
已结题
起止时间：
2018-11-01 至 2021-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=398880&lang=en
关键词：
Cellular Senescence Dna Damage Epigenetics Healthspan Inflammation Mrna Translation Organismal Aging Progeroid Syndromes Reactive Oxygen Species

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英文摘要
Gradual decline of physical functions during aging increases susceptibility to chronic diseases and inevitably lead to increased health expenditures, morbidity and mortality. During the lifespan, cells within the organism undergo numerous stresses that ca
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Identifying novel therapeutic vulnerabilities in pediatric acute megakaryoblastic leukemia
Exploiting translational reprogramming in neoplasia to devise unique strategies to eliminate cancer and cancer-promoting senescent cells
Canada Research Chairs - Tier 2
  • 批准号：
    441821
  • 项目类别：
  • 资助金额：
    $36.43万
  • 财政年份：
    2020
  • 负责人：
    Mallette Frdrick A
  • 依托单位：
    Universit de Montral
Cholesterol metabolism and regulation of the senescence-associated secretory phenotype in retinopathy
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