Advanced Cellular Microenvironments

先进的细胞微环境

• 批准号: 1000230802-2015
• 负责人: Moraes, Christopher
• 金额: $ 8.74万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=660148
• 关键词: Advanced; Cellular; Microenvironments

Cells in the body are exposed to complex combinations of mechanical, chemical, and adhesive signals that play a pivotal role in regulating cell function. However, the vast majority of biological experiments are conducted on static, hard, flat, dishes. The proposed Canada Research Chair in Advanced Cellular Microenvironments aims to bridge the gap between the well-controlled, yet unrealistic Petri dish, and the chaotic, but physiological animal and human models. Through integrated microscale engineering, optical microscopy and tissue engineering approaches, this research program will develop the critical systems necessary to improve translation of discoveries from the bench towards clinical applications.

人体内的细胞暴露在机械、化学和黏附信号的复杂组合中，这些信号在调节细胞功能方面发挥着关键作用。然而，绝大多数生物实验都是在静态、坚硬、平坦的盘子上进行的。拟议的加拿大高级细胞微环境研究教席旨在弥合控制良好但不切实际的培养皿与混乱但生理的动物和人类模型之间的差距。通过集成的微尺度工程、光学显微镜和组织工程方法，该研究计划将开发必要的关键系统，以改进从试验台到临床应用的发现转化。