Advanced Cellular Microenvironments

点击翻译按钮获取中文摘要

Organoids have shown strong potential as personalized models for disease, but are challenging to scale up, analyze, and direct towards specific structures and functions. This research program will develop high-throughput organoid production platforms,integrate sensing technologies for functional readouts, and tune organoid culture environments to better capture neurodegenerative and cancer disease processes. These advances will be driven by understanding and recreating the dynamic physical forces that arise during tissue formation, and requires the development of innovative engineering tools leveraging microfabrication and biomaterial design. These fundamental studies will have ultimate applications in disease modelling, predictive diagnostics, and improved drug discovery.