Spectrofluorometer for Advanced Materials Characterization and Sensor Development

用于先进材料表征和传感器开发的分光荧光计

• 批准号: RTI-2019-00328
• 负责人: Mutus, Bulent
• 金额: $ 10.93万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=660523
• 关键词: Spectrofluorometer; Advanced; Materials; Characterization; Sensor

The chemical properties of many molecules enable them to absorb energy from light, and in the process, be converted to an excited state. The molecules in their excited states release their excitation energy in the form of light or heat. The requested spectrofluorometer, enables the measurement of the photophysical properties of matter, including, amount of energy required to excite the molecule, the type of excitation state, the lifetime or how long the molecule remains in its excited state(s), the energy or colour of the emitted light, and how efficiently the absorbed energy is converted to the emitted light. The ability to measure these parameters enables researchers to tune the structure of materials to optimize the performance of devices like solar cells, light emitting diodes (LED), transistors, dyes and optical sensors with applications in bioimaging, diagnostics and the sensitive and specific detection of analytes including environmental contaminants, etc. The spectrofluorometer is requested by a group of NSERC-funded researchers, engaged in materials, biomaterials, and biochemistry research, with a total of over $2.1M in funding (DG, RTI, Engage, CRC, CFI/ORF) in the past three years. However, both their short-term research progress and the longer-term impact of their research programs is severely hampered by the lack of a state-of-the-art spectrofluorometer capable of lifetime and steady state fluorescence measurements of solids, films, gels and solutions, with high sensitivity. The requested instrument is an essential addition to the suite of tools for the design and characterization of advanced materials. The University has recently demonstrated strong commitment to Advanced Materials Research with a new research building (Essex CORe), the strategic filling of four new positions in Chemistry & Biochemistry with soft materials researchers (Trant, Marquardt, Rondeau-Gagné and Tong) to complement existing strengths in Materials science led by Loeb, Rawson, Eichhorn, Schurko and Carmichael and the founding of a cross disciplinary research institute (WINRAM). The University's strong commitment to the User Group and to Advanced Materials Research continues with the provision of an additional $29,615 to supplement the requested funding for this proposal. The requested spectrofluorometer will support research programs of 8 groups (5-applicants and 3-frequent users) including a Tier 1 CRC, across 3 Departments and aid in the training of many HQP in an essential molecular characterization technique. The research outcomes aided by the requested instrument include, inorganic and organic dyes for industrial catalysis; molecular machines that move in response to light; light emitting nanoparticles for displays; dynamic monitoring of cellular membrane architecture; development of materials for delivery of drugs and imaging agents; live monitoring of enzymes in cells; and the detection of environmental contaminants.

许多分子的化学性质使它们能够从光中吸收能量，并在这个过程中被转化为激发态。处于激发态的分子以光或热的形式释放其激发能量。所要求的光谱荧光仪能够测量物质的光物理性质，包括激发分子所需的能量、激发状态的类型、分子的寿命或保持其激发状态的时间(S)、发射的光的能量或颜色，以及吸收的能量转化为发射的光的效率。测量这些参数的能力使研究人员能够调整材料结构，以优化太阳能电池、发光二极管(LED)、晶体管、染料和光学传感器等器件的性能，这些器件应用于生物成像、诊断以及对包括环境污染物在内的分析物进行灵敏和特异的检测等。然而，他们的短期研究进展和研究计划的长期影响都严重阻碍了他们的研究计划，因为缺乏一种能够以高灵敏度测量固体、薄膜、凝胶和溶液的寿命和稳态荧光的最先进的荧光光谱仪。所要求的仪器是先进材料设计和表征工具套件的重要补充。该大学最近表现出对先进材料研究的坚定承诺，建立了一座新的研究大楼(埃塞克斯核心)，战略地用软材料研究人员(Trant、MarQuardt、Rondeau-gagné和童)填补了化学和生物化学的四个新职位，以补充由Loeb、Rawson、Eichhorn、Schurko和Carmichael领导的材料科学的现有优势，并建立了一个跨学科研究所(Winram)。大学对用户组和先进材料研究的坚定承诺继续提供额外的29615美元，以补充这项提议所要求的资金。申请的荧光分光光度计将支持8个小组(5名申请者和3名经常使用者)的研究计划，包括1级CRC，跨越3个部门，并帮助许多HQP在基本分子表征技术方面的培训。所要求的仪器协助取得的研究成果包括：用于工业催化的无机和有机染料；随光移动的分子机器；用于显示器的发光纳米颗粒；细胞膜结构的动态监测；药物和显像剂输送材料的开发；细胞内酶的实时监测；以及环境污染物的检测。