Redox signaling in vascular cells

血管细胞中的氧化还原信号传导

• 批准号: 2542-2011
• 负责人: Mutus, Bulent
• 金额: $ 2.91万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=592721
• 关键词: Redox; signaling; vascular; cells

Nitric oxide (NO) and hydrogen sulfide (H2S) are important signaling molecules produced in the body. They play major roles in the function as well as dysfunction of the nervous system, immune system and the circulatory system. NO and H2S are very reactive compounds that react with each other as well as with oxygen and biomolecules to form both stable and unstable derivatives that help mediate their physiological and pathological effects. However, whether the cellular processes initiated by NO and H2S are independent or augmented or counteracted by each other, is poorly understood.

一氧化氮（NO）和硫化氢（H2S）是体内产生的重要信号分子。它们在神经系统、免疫系统和循环系统的功能和功能障碍中起着重要作用。NO和H2S是非常活泼的化合物，它们彼此反应以及与氧和生物分子反应，形成稳定和不稳定的衍生物，有助于介导它们的生理和病理作用。然而，由NO和H2S引发的细胞过程是独立的还是相互增强或抵消的，知之甚少。