Hybrid Biomaterials for Orthopedic and Craniofacial Applications

用于骨科和颅面应用的混合生物材料

• 批准号: RGPIN-2017-04983
• 负责人: Rizkalla, Amin
• 金额: $ 1.75万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=663429
• 关键词: Hybrid; Biomaterials; Orthopedic; Craniofacial; Applications

The rise in life expectancy in developed countries has led to an increase in age-related skeletal diseases such as osteoarthritis, osteoporosis and periodontitis with corresponding increase in demand for materials that can replace and integrate with bone. In addition, over 2.2 million patients per year worldwide undergo surgery for skeletal trauma or tumor resection. The gold standard for bone repair is the autograft. However, limited tissue availability and donor-site morbidity has led to the use of artificial materials. Despite intensive research efforts in the fields of ceramics, metals and polymers, the ideal material is still far from clinical practice. Over the next 5 years, the proposed research program will focus on developing: 1) hybrid scaffolds and vehicles for the controlled release of bioactive and antibacterial molecules; 2) bioactive and antimicrobial hybrid coatings on functionalized 3-D-printed titanium alloys to enhance the interfacial bond with bone; and 3) novel, fast setting and injectable bone cements, which are bioactive and biodegradable. The proposed work will improve our fundamental understanding of and lead to technological breakthroughs in covalently bonded class II hybrid biomaterials for scaffolds, implant coatings, and cements for use in orthopedic, craniofacial and periodontal applications. In addition, I will train well-rounded graduate and undergraduate students in the field of bone tissue engineering and regenerative medicine. The overall program will provide training for three PhD, two Masters and six undergraduate students, exposing them to cutting edge research and development in the synthesis and characterization of hybrid biomaterials. Upon graduation, these students will take leadership roles in bringing biotechnology and medical devices from the laboratory to the marketplace and clinic.**

发达国家预期寿命的增加导致与年龄相关的骨骼疾病增加，如骨关节炎、骨质疏松症和牙周炎，对可替代骨并与骨结合的材料的需求相应增加。此外，全世界每年有超过220万患者接受骨骼创伤或肿瘤切除手术。骨修复的金标准是自体移植。然而，有限的组织可用性和供体部位的发病率导致了人工材料的使用。尽管在陶瓷、金属和聚合物领域进行了深入的研究，但理想的材料离临床实践还很远。在未来5年内，拟议的研究计划将重点开发：1）用于生物活性和抗菌分子受控释放的混合支架和载体; 2）功能化3D打印钛合金上的生物活性和抗菌混合涂层，以增强与骨的界面结合;和3）新型、快速凝固和可注射的骨水泥，具有生物活性和可生物降解性。拟议的工作将提高我们的基本理解，并导致共价键合的第二类混合生物材料的支架，植入物涂层和骨水泥用于骨科，颅面和牙周应用的技术突破。此外，我将培养全面的研究生和本科生在骨组织工程和再生医学领域。整个计划将为三名博士，两名硕士和六名本科生提供培训，使他们接触到混合生物材料合成和表征的前沿研究和开发。毕业后，这些学生将在将生物技术和医疗设备从实验室带到市场和诊所方面发挥领导作用。