Genetic and molecular analysis of the siRNA-mediated silencing pathway in C. elegans.

线虫中 siRNA 介导的沉默途径的遗传和分子分析。

• 批准号: 326845-2013
• 负责人: Simard, Martin
• 金额: $ 3.13万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=665214
• 关键词: Genetic; molecular; analysis; siRNA; mediated

In the recent years, the breakthrough discovery of a new way cell controls its material production have proven once again that biology has yet unexpected things to be found by researchers. Using the round worm as model animal, the discovery of this new pathway called RNA interference or RNAi was acknowledged by the Nobel Committee in 2006 for its real potential in the development of RNAi-related technologies triggers by a small molecules called siRNA that are extremely useful for biology research and for pharmaceutical industries.****Our research group will pursue his research on siRNA-mediated gene regulation using the round worm as a model in order to better understand the details of this biological phenomenom. We believe that our innovative research program will contribute to a better use in the future of the siRNAs as a molecular technology in research laboratories as well as new therapeutic agents.

近年来，细胞控制其物质生产的新途径的突破性发现再次证明，生物学还没有发现研究人员意想不到的事情。利用蛔虫作为模型动物，这种称为RNA干扰或RNAi的新途径的发现在2006年获得诺贝尔委员会的认可，因为它在开发RNAi相关技术方面的真实的潜力，这些技术由一种称为siRNA的小分子触发，对生物学研究和制药工业非常有用。我们的研究小组将继续他的研究siRNA介导的基因调控使用蛔虫作为模型，以更好地了解这种生物现象的细节。我们相信，我们的创新研究计划将有助于在未来更好地使用siRNA作为研究实验室的分子技术以及新的治疗药物。