Microalgae fermentation on C5 sugar from hemicellulose waste: Multi-omic analysis and modeling for rational bioprocess engineering

半纤维素废物中的 C5 糖发酵微藻:合理生物过程工程的多组学分析和建模

基本信息

  • 批准号:
    531377-2018
  • 负责人:
  • 金额:
    $ 1.82万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Engage Grants Program
  • 财政年份:
    2018
  • 资助国家:
    加拿大
  • 起止时间:
    2018-01-01 至 2019-12-31
  • 项目状态:
    已结题

项目摘要

Mara Renewables Corporation is an Atlantic Canadian producer of algal-based bio-products. The company is**seeking to expand its production to include biofuels, but it is currently limited by the high cost of carbon**sources. The goal of this project is to develop a metabolic model capable to identifying a genetic engineering**strategy that would enable the company's microalgae to use hemicellulose - a byproduct of the pulp and paper**industry, produced in large quantities in Nova Scotia and Canada more broadly. Hemicellulose is primarily**composed of five-carbon (C5) sugar, which the microalgae are not able to process effectively. The project will**focus on using nuclear magnetic resonance (NMR) analysis to identify the metabolic role of C5 sugar and**integrate this data into a model to determine how to increase C5 utilization through genetic engineering. A**successful outcome will enable Mara to produce cheap and sustainable biofuel, benefiting the Canadian**consumer and Canadian industry through export potential and further economic development.**
玛拉可再生能源公司是一家位于加拿大大西洋沿岸的藻类生物产品生产商。该公司正在寻求扩大其生产,包括生物燃料,但目前受到高成本碳源的限制。该项目的目标是开发一种代谢模型,能够确定一种基因工程策略,使该公司的微藻能够利用半纤维素——一种纸浆和造纸工业的副产品,在新斯科舍省和加拿大大量生产。半纤维素主要由五碳(C5)糖组成,微藻无法有效地处理。该项目将**侧重于利用核磁共振(NMR)分析来确定C5糖的代谢作用,并**将这些数据整合到一个模型中,以确定如何通过基因工程提高C5的利用率。一个成功的结果将使玛拉能够生产廉价和可持续的生物燃料,通过出口潜力和进一步的经济发展使加拿大消费者和加拿大工业受益

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Sokolenko, Stanislav其他文献

Detection of highly overlapping peaks via adaptive apodization
  • DOI:
    10.1016/j.jmr.2021.107104
  • 发表时间:
    2021-11-19
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    MacDonald, Ruis;Sokolenko, Stanislav
  • 通讯作者:
    Sokolenko, Stanislav
Atrial natriuretic peptide signaling co-regulates lipid metabolism and ventricular conduction system gene expression in the embryonic heart.
  • DOI:
    10.1016/j.isci.2023.108748
  • 发表时间:
    2024-01-19
  • 期刊:
  • 影响因子:
    5.8
  • 作者:
    Mishra, Abhishek;Tavasoli, Mahtab;Sokolenko, Stanislav;Mcmaster, Christopher R.;Pasumarthi, Kishore B. S.
  • 通讯作者:
    Pasumarthi, Kishore B. S.
Construction and analysis of a genetically tuneable lytic phage display system.
  • DOI:
    10.1007/s00253-013-4898-6
  • 发表时间:
    2013-09
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Nicastro, Jessica;Sheldon, Katlyn;El-zarkout, Farah A.;Sokolenko, Stanislav;Aucoin, Marc G.;Slavcev, Roderick
  • 通讯作者:
    Slavcev, Roderick
Robust 1D NMR lineshape fitting using real and imaginary data in the frequency domain
  • DOI:
    10.1016/j.jmr.2018.11.004
  • 发表时间:
    2019-01-01
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    Sokolenko, Stanislav;Jezequel, Tangi;Giraudeau, Patrick
  • 通讯作者:
    Giraudeau, Patrick

Sokolenko, Stanislav的其他文献

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{{ truncateString('Sokolenko, Stanislav', 18)}}的其他基金

Combining high throughput metabolomics with real-time biosensors to study the oxidative state in cell culture producing recombinant proteins.
将高通量代谢组学与实时生物传感器相结合,研究生产重组蛋白的细胞培养物中的氧化状态。
  • 批准号:
    RGPIN-2019-04694
  • 财政年份:
    2022
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Discovery Grants Program - Individual
Combining high throughput metabolomics with real-time biosensors to study the oxidative state in cell culture producing recombinant proteins.
将高通量代谢组学与实时生物传感器相结合,研究生产重组蛋白的细胞培养物中的氧化状态。
  • 批准号:
    RGPIN-2019-04694
  • 财政年份:
    2021
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Discovery Grants Program - Individual
Combining high throughput metabolomics with real-time biosensors to study the oxidative state in cell culture producing recombinant proteins.
将高通量代谢组学与实时生物传感器相结合,研究生产重组蛋白的细胞培养物中的氧化状态。
  • 批准号:
    RGPIN-2019-04694
  • 财政年份:
    2020
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Discovery Grants Program - Individual
Combining high throughput metabolomics with real-time biosensors to study the oxidative state in cell culture producing recombinant proteins.
将高通量代谢组学与实时生物传感器相结合,研究生产重组蛋白的细胞培养物中的氧化状态。
  • 批准号:
    DGECR-2019-00427
  • 财政年份:
    2019
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Discovery Launch Supplement
Combining high throughput metabolomics with real-time biosensors to study the oxidative state in cell culture producing recombinant proteins.
将高通量代谢组学与实时生物传感器相结合,研究生产重组蛋白的细胞培养物中的氧化状态。
  • 批准号:
    RGPIN-2019-04694
  • 财政年份:
    2019
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Discovery Grants Program - Individual
Elucidating the xylose metabolism pathway in thraustochytrids for the conversion of hemicellulosic waste into omega-3 fatty acids and biofuel.
阐明破囊壶菌中将半纤维素废物转化为 omega-3 脂肪酸和生物燃料的木糖代谢途径。
  • 批准号:
    543628-2019
  • 财政年份:
    2019
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Collaborative Research and Development Grants
Expanding the NMR metabolomics toolbox by constraining the feasible solution space
通过限制可行的解决方案空间扩展 NMR 代谢组学工具箱
  • 批准号:
    502476-2017
  • 财政年份:
    2016
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Postdoctoral Fellowships
Rational metabolic flux analysis model generation and verification through Monte Carlo simulation: Application to insect cell culture
通过蒙特卡罗模拟生成和验证合理的代谢流分析模型:在昆虫细胞培养中的应用
  • 批准号:
    441909-2013
  • 财政年份:
    2015
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Rational metabolic flux analysis model generation and verification through Monte Carlo simulation: Application to insect cell culture
通过蒙特卡罗模拟生成和验证合理的代谢流分析模型:在昆虫细胞培养中的应用
  • 批准号:
    441909-2013
  • 财政年份:
    2014
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Rational metabolic flux analysis model generation and verification through Monte Carlo simulation: Application to insect cell culture
通过蒙特卡罗模拟生成和验证合理的代谢流分析模型:在昆虫细胞培养中的应用
  • 批准号:
    441909-2013
  • 财政年份:
    2013
  • 资助金额:
    $ 1.82万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral

相似国自然基金

微生物发酵过程的自组织建模与优化控制
  • 批准号:
    60704036
  • 批准年份:
    2007
  • 资助金额:
    21.0 万元
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人工智能优化发酵,从食品副产品中可持续生产蛋白质
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