The role of the folliculostellate cells of the anterior pituitary in the regulation of hormone secretion.

垂体前叶滤泡细胞在激素分泌调节中的作用。

• 批准号: 194652-2012
• 负责人: Vitale, MaríaLeiza
• 金额: $ 1.82万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=667836
• 关键词: role; folliculostellate; cells; anterior; pituitary

The anterior pituitary gland secretes hormones that control development, basal metabolism, the immune response and reproduction. Therefore, the regulation of hormone release by this gland is essential for survival. Our aim is to understand the control of anterior pituitary hormone secretion. In the present proposal we will investigate whether intercellular communication among folliculostellate cells in the anterior pituitary gland contributes to the regulation of the anterior pituitary endocrine function. Differently from the hormone producing-cells, the folliculostellate cells do not release hormones but, instead, they secrete substances that act within the anterior pituitary gland to control the release of anterior pituitary hormones. In addition, the folliculostellate cells communicate with other folliculostellate and endocrine cells within the anterior pituitary. Cell-to-cell communication mainly occurs via specialized structures known as gap junctions. Gap junctions are intercellular channels formed by a family of proteins known as connexins. Six connexin molecules associate to form a connexon or hemichannel, and the docking of two hemichannels from neighbouring cells forms a gap junction channel. Cell coupling is an effective mode of controlling and synchronizing hormone secretion. We will study whether gap junction-mediated cell-to-cell communication among the folliculostellate cells is affected by endogenous substances such as cytokines and growth factors known to modulate hormone secretion. The present study will provide a deeper understanding of the regulation of hormone secretion by the folliculostellate cells.**

脑下垂体前叶分泌激素，控制发育、基础代谢、免疫反应和生殖。因此，该腺体对激素释放的调节对生存至关重要。我们的目的是了解垂体前叶激素分泌的控制。在本研究中，我们将探讨垂体前叶滤泡星状细胞之间的细胞间通讯是否有助于调节垂体前叶的内分泌功能。与荷尔蒙产生细胞不同，卵泡星状细胞不释放荷尔蒙，而是分泌在脑下垂体内活动的物质，以控制脑下垂体前叶荷尔蒙的释放。此外，垂体腺前叶内的毛囊星状细胞与其他毛囊星状细胞和内分泌细胞相互联系。细胞间的通讯主要通过称为缝隙连接的特殊结构进行。缝隙连接是由连接蛋白家族形成的细胞间通道。六个连接蛋白分子结合形成连接蛋白或半通道，来自相邻细胞的两个半通道对接形成缝隙连接通道。细胞偶联是控制和同步激素分泌的有效方式。我们将研究缝隙连接介导的滤泡星状细胞之间的细胞间通讯是否受到内源性物质的影响，如细胞因子和已知的调节激素分泌的生长因子。本研究将对卵泡星状细胞激素分泌的调节提供更深入的了解。