Discovery and Creation of Metal Carbonyl (MC) Supramolecular Chemistry

基于Wang博士发明的迁移插入聚合(MIP)和金属羰基(MC)自组装囊泡的最新发现，提出了MC超分子化学。这项工作的原创性和新颖性将为超分子化学、有机金属聚合物和胶体等领域的研究带来新的方向。有了足够的支持，王博士将成为这些领域的国际领导者。*王博士发现，疏水、非表面活性的CpPPh3Fe(CO)CO(CH2)5CH3(FpC6)作为MC构建块，可以在水中自组装成具有高度膜集成度的均匀囊泡。胶体是通过水-羰基相互作用(WCI)、疏水水化作用(HH)和疏水相互作用(HI)的平衡来稳定的。MC的这种水溶液行为与许多自然系统相似，例如蛋白质。因此，MC超分子化学将提供一个实验系统来验证WCI、HH和HI的任意理论，这些理论主要建立在复杂的生物系统和计算化学的基础上。*FpC6还能够通过分子间pi-pi相互作用和以CO为受体的氢键，在固体中组装成第一个表征良好的超分子双链。这一发现是通过反向晶体工程实现的。通过改变MC的化学结构、组装条件和添加剂，出现了学习多种相互作用的协同作用的不同寻常的机会，这是设计合成所必需的。这种罕见的双链是一种潜在的有用材料，它结合了大分子和局部有序MC基团的性质，为工业研究提供了新的概念。*分子印迹聚合物允许我们获得一组新的大分子MC构筑块、PFPP及其衍生物。除了WCI、HH和HI外，PFPP的组装与蛋白质一样，与链构象和动力学稳定性有关。这两个方面的研究将有助于我们对自然系统的理解，并开发仿生材料的概念。PFPP是疏水性的，在水中也能组装成囊泡。囊泡膜很薄，但高度整合，表面覆盖着MC。这一独特的功能将被探索作为纳米反应器和水中污染物的清除剂的潜在应用。*这项研究将：1)建立一个连接自然组装系统和超分子化学的实验系统；2)创造新材料的新概念；3)推进一些科学前沿，包括有机金属聚合物、超分子化学和水性胶体；4)提供尖端培训平台。因此，加拿大的科学和工业将受益于预期的世界第一的知识和背后的HQP。

Based on Dr Wang's invention of migration insertion polymerization (MIP) and recent discoveries of metal carbonyl (MC) self-assembled vesicles, MC supramolecular chemistry is proposed. The originality and novelty of the proposed work will lead to new directions of research for several fields, including supramolecular chemistry, organometallic polymer and colloids. With sufficient support, Dr Wang will be an international leader in these fields.******Dr Wang discovered that hydrophobic, non-surface active CpPPh3Fe(CO)CO(CH2)5CH3 (FpC6), as an MC building block, can self-assemble in water into uniform vesicles with high membrane integration. The colloids are stabilized via the balance of water-carbonyl interaction (WCI), hydrophobic hydration (HH) and hydrophobic interaction (HI). This aqueous behavior of MCs bears a resemblance to many natural systems, e.g. proteins. MC supramolecular chemistry will therefore offer an experimental system to verify the arbitrary theories for WCI, HH and HI established mainly based on complicated biological systems and computation chemistry. ***FpC6 is also able to assemble in solid state into the first example of well-characterized supramolecular duplex chains via intermolecular pi-pi interaction and hydrogen bonding with CO as acceptor. This discovery is achieved via reverse crystal engineering. By varying the chemical structure of MCs, assembling conditions and additives, unusual opportunities arise to learn the synergy of multiple interactions that is essential for designed synthesis. The duplex chains, rarely observed, are potentially useful materials with combined properties of macromolecules and locally ordered MC groups, providing new concepts for industrial R & D.***MIP allows us to access a novel group of macromolecular MC building blocks, PFpPs and their derivatives. In addition to WCI, HH and HI, the assembly of PFpPs, like proteins, is related to chain conformation and kinetic stability. These two aspects will be studied to assist our understanding of natural systems and develop concepts for bio-mimic materials. PFpP is hydrophobic and also able to assemble into vesicles in water. The vesicular membrane is thin, but highly integrated, with a surface covered with MCs. This unique feature will be explored for potential applications as nanoreactors and scavengers for contaminants in water. ***This research will: 1) create an experimental system bridging natural assembling systems and supramolecular chemistry; 2) create new concepts for novel materials; 3) advance a number of scientific frontiers, including organometallic polymers, supramolecular chemistry and aqueous colloids; 4) provide a cutting-edge training platform. Canadian science and industry will therefore benefit from the expected world-firsts in knowledge and HQPs behind them.******