Comprehensive Drug Surveillance by Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry: Insights into Medicinal Cannabis Metabolism..
多段注射-毛细管电泳-质谱综合药物监测:深入了解药用大麻代谢..
基本信息
- 批准号:543226-2019
- 负责人:
- 金额:$ 1.81万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Engage Grants Program
- 财政年份:2019
- 资助国家:加拿大
- 起止时间:2019-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Medicinal cannabis is of great scientific and public interest to Canadians that promises major socioeconomic benefits. However, there remains a lack of scientific studies that can guide the development of evidence-based cannabis therapeutics for treatment of debilitating health conditions, such as chronic pain. The cannabis plant is a polypharmaceutical substance containing more than 500 chemical constituents, including 100 different cannabinoids whose synergistic biological activities remain poorly understood. To date, guidelines from Health Canada focus on analytical testing for potency of only two cannabinoids (THC, CDB) that do not fundamentally address how patients metabolize cannabinoids. Indeed, dosage regimes and treatment responses vary widely between patients resulting in sub-optimal responses with potential adverse effects from lifestyle (e.g., tobacco) and concurrent medications (e.g., opioids). Our proposal aims to address this major knowledge gap based on a collaborative research project between researchers at McMaster University and PureSinse, a licensed producer with interests in developing innovative medicinal cannabis products tailored to individual patients. Our study will recruit both first-time and returning patients who are being treated for chronic pain, anxiety and/or insomnia. Our proposal will perform comprehensive drug surveillance on paired urine samples collected from patients over a three week period during clinical visits who have been prescribed either dried plants (smoked/vaped) or oil extracts (ingested). Importantly, our data workflow will include non-targeted metabolite profiling in urine for the discovery of novel cannabinoid metabolites and other relevant drug exposures not screened by conventional tests. This approach will not only confirm patient adherence but also reveal differential cannabinoid metabolism between patients from inhaled or ingested cannabis products, including potential adverse effects with other prescribed drugs. Our exciting pilot study will provide healthcare providers an objective yet accurate screening tool that guides optimal medicinal cannabis prescriptions for improved treatment outcomes in patients.
医用大麻对加拿大人具有重大的科学和公共利益,有望带来重大的社会经济利益。然而,仍然缺乏科学研究来指导开发以证据为基础的大麻疗法,用于治疗慢性疼痛等令人衰弱的健康状况。大麻植物是一种多药物物质,含有500多种化学成分,包括100种不同的大麻类化合物,其协同生物活性仍鲜为人知。到目前为止,加拿大卫生部的指南侧重于对两种大麻素(THC、CDB)的效力进行分析测试,这两种大麻素没有从根本上解决患者如何代谢大麻素的问题。事实上,患者之间的剂量方案和治疗反应差异很大,导致反应不佳,生活方式(如烟草)和同时用药(如阿片类药物)可能产生不良影响。我们的提案旨在解决这一重大知识差距,该项目是麦克马斯特大学的研究人员和PureSinse之间的一个合作研究项目,PureSinse是一家获得许可的生产商,有兴趣开发为个人患者量身定做的创新药用大麻产品。我们的研究将招募正在接受慢性疼痛、焦虑和/或失眠治疗的首次患者和回归患者。我们的建议将对在临床就诊期间从患者那里收集的尿液样本进行全面的药物监测,这些患者在临床就诊期间服用了干植物(烟熏/蒸发)或油提取物(摄入)。重要的是,我们的数据工作流程将包括尿液中的非靶向代谢物分析,以发现新的大麻类代谢物和其他未经常规测试筛选的相关药物暴露。这一方法不仅将确认患者的依从性,还将揭示吸入或摄入大麻产品的患者之间的大麻素代谢差异,包括与其他处方药的潜在不良反应。我们令人兴奋的试点研究将为医疗保健提供者提供一个客观而准确的筛查工具,指导最佳医用大麻处方,以改善患者的治疗结果。
项目成果
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BritzMckibbin, Philip其他文献
BritzMckibbin, Philip的其他文献
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{{ truncateString('BritzMckibbin, Philip', 18)}}的其他基金
New Advances in Capillary Electrophoresis-Mass Spectrometry for Metabolomics: Multiplexed Separations for Biomarker Discovery
代谢组学毛细管电泳质谱新进展:生物标志物发现的多重分离
- 批准号:
RGPIN-2014-03987 - 财政年份:2019
- 资助金额:
$ 1.81万 - 项目类别:
Discovery Grants Program - Individual
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