Coupling ultrasound and precision mechanical testing to measure large deformation in vivo tissue mechanical properties.

耦合超声和精密机械测试来测量体内大变形组织的机械性能。

• 批准号: 543823-2019
• 负责人: Sparrey, Carolyn
• 金额: $ 1.82万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=680410
• 关键词: Coupling; ultrasound; precision; mechanical; testing

Clarius designs a range of wireless ultrasound systems providing high image quality for medical and research applications. Ultrasound technology can be used to measure tissue material properties in addition to imaging and this can be important for diagnosing or understanding clinical conditions. However, using ultrasound to measure tissue properties has so far been limited to measuring only small deformations or measuring relative differences in tissues but not directly measuring properties. The primary objective of this project is to explore the possibility of linking ultrasound with precision mechanical testing to develop a protocol to quantify large deformation soft tissue properties in live humans. In order to do this we will need to first design some custom fixtures to integrate the two systems and design an experimental protocol that can be easily repeated across different human test subjects. Finally we will conduct a pilot trial with 15 human test subjects to assess the integrated system to compare the tissue mechanics predicted by traditional elastography methods with the large deformation properties measured by the integrated system. The benefit to Canada of this research is two-fold, supporting the development of novel products at a Canadian company and demonstrating the potential value of tissue mechanics for non-invasively diagnosing medical conditions.

Clarius设计了一系列无线超声系统，为医疗和研究应用提供高质量的图像。除了成像之外，超声技术还可用于测量组织材料特性，这对于诊断或了解临床状况非常重要。然而，使用超声波来测量组织特性到目前为止仅限于测量小的变形或测量组织中的相对差异，而不是直接测量特性。该项目的主要目标是探索将超声与精密机械测试相结合的可能性，以开发一种协议来量化活体人体中大变形软组织的特性。为了做到这一点，我们首先需要设计一些定制的夹具来集成两个系统，并设计一个可以在不同的人类测试对象中轻松重复的实验方案。最后，我们将与15名人体测试对象进行试点试验，以评估集成系统，比较传统弹性成像方法预测的组织力学与集成系统测量的大变形特性。这项研究对加拿大的好处是双重的，支持加拿大公司开发新产品，并证明组织力学对非侵入性诊断医疗条件的潜在价值。