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Microwave-enhanced synthesis of Au and Ag nanoparticles

金和银纳米粒子的微波增强合成

基本信息

批准号：
537811-2019
负责人：
Ma, Dongling
金额：
$ 1.82万
依托单位：
Institut national de la recherche scientifique
依托单位国家：
加拿大
项目类别：
Engage Grants Program
财政年份：
2019
资助国家：
加拿大
起止时间：
2019-01-01 至 2020-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=680889
关键词：
Microwave enhanced synthesis Au Ag

项目摘要

SKNANO has been dedicated to research and development, prototyping, testing, innovative synthesis and fabrication of gold and silver nanoparticles, mainly for biomedical applications. For pharmaceutical and bio-related applications, uniform nanoparticles, highly reproducible in both size and shape, are strictly required. Otherwise, their bio-conjugation and subsequent performance during bio-related processes can be quite different, largely increasing complicity of data analysis and introducing data/performance inconsistency. It is however still challenging to achieve high batch-to-batch reproducibility, especially for ultrasmall, rough, high-surface-area nanoparticles. Microwave-assisted synthesis, using microwave irradiation to provide rapid and uniform inside-out heating directly to reactants, can provide much more precise control over reaction conditions than any previous technology and represents a unique tool to synthesizing nanoparticles with very high reproducibility. The main goal of this short project is to develop microwave-enhanced synthesis routes in order to obtain uniform, stable colloidal solutions of very small Au and Ag NPs, with high batch-to-batch reproducibility. Meanwhile, we are also interested in establishing the relationship between ligands, nanoparticle growth mechanism under microwave, surface chemistry, and colloidal stability in dispersion, which can provide guides for future material development.

SKNANO一直致力于金银纳米颗粒的研发、原型设计、测试、创新合成和制造，主要用于生物医学应用。对于制药和生物相关应用，严格要求尺寸和形状均一、高度可重复的纳米颗粒。否则，它们在生物相关过程中的生物结合和后续性能可能会有很大不同，很大程度上增加了数据分析的复杂性并引入数据/性能不一致。然而，实现批次间的高重现性仍然具有挑战性，特别是对于超小、粗糙、高表面积的纳米粒子。微波辅助合成利用微波辐射直接向反应物提供快速、均匀的由内而外的加热，可以比任何以前的技术提供对反应条件更精确的控制，并且代表了一种具有极高重现性的合成纳米颗粒的独特工具。这个短期项目的主要目标是开发微波增强合成路线，以获得均匀、稳定的非常小的金和银纳米粒子的胶体溶液，并且具有高批次重现性。同时，我们也有兴趣建立配体、微波下纳米粒子生长机制、表面化学和分散中胶体稳定性之间的关系，这可以为未来材料的开发提供指导。