Nanotechnology Engineering

纳米技术工程

• 批准号: 1000231345-2016
• 负责人: Gu, Frank
• 金额: $ 1.82万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=680939
• 关键词: Nanotechnology; Engineering

Microbial keratitis is a form of eye infection that affects over 1 million people every year and can cause blindness when left untreated. The proposed program will develop novel pathogen sensing and therapeutic delivery technologies to tackle unique challenges in the detection and treatment of microbial keratitis. Dr. Gu's team will formulate mucoadhesive nanoparticles to deliver antimicrobial therapeutics directly to the infected tissues, and apply colorimetric gold nanoparticles for the rapid detection of pathogens in biofilms, a critical source of ocular infection. This research will lay the groundwork for new therapeutics and diagnostic tools for a range of eye diseases.

微生物性角膜炎是一种眼部感染，每年影响超过100万人，如果不及时治疗，可能导致失明。该计划将开发新型病原体传感和治疗输送技术，以应对微生物角膜炎检测和治疗方面的独特挑战。Gu博士的团队将配制粘膜粘附纳米颗粒，将抗菌治疗剂直接输送到受感染的组织，并应用比色金纳米颗粒快速检测生物膜中的病原体，这是眼部感染的关键来源。这项研究将为一系列眼科疾病的新疗法和诊断工具奠定基础。