Understanding formulation characteristics on the glass transition of spray powders fortified with cannabis oils

在加拿大，大麻目前在娱乐市场上作为干燥植物材料或通过油和溶液口服，以及奇怪的个人性润滑剂（Fleure de Lune: HEXO Corp）被规定或出售。虽然大麻通常是吸食的，但吸入烧焦的干燥植物物质显然与固有的健康风险有关，即使是一小部分烟草也不可接受。难道我们没有从烟草业吸取教训吗？口服消除了与吸入热解产物相关的肺部健康风险，并允许对四氢大麻酚和CBD等有效成分进行准确剂量。不幸的是，由于大麻素的溶解度和分散性差，使得产品的生物利用度非常低，挑战阻碍了口服产品的市场增长。我们打算研究含大麻油的可流动粉末的设计。将大麻油添加到诸如麦芽糖糊精（通常是一种优秀的玻璃状载体粉末）之类的粉末中，降低其玻璃化转变温度，导致最终动力具有粘性，流动性能差，这将导致消费者缺乏接受度。设计了三元相图，研究了麦芽糖糊精载体油-大麻油喷雾干粉的流动性、分散性和玻璃化转变温度。该信息的行业目标是允许Motif设计一种货架稳定的麦芽糊精大麻浓缩成分，可能用于可食用的娱乐市场，或者可以进一步加工并压缩成医疗市场的表格（超出本协议的范围）。

In Canada, cannabis currently is prescribed or sold on the recreational market as dried plant material or orally administered via oils and solutions, and oddly as personal sex lubricant (Fleure de Lune: HEXO Corp). While cannabis is typically smoked, inhalation of burned, dry plant matter is obviously associated with inherent health risks which are unacceptable even if at a fraction of tobacco. Have we learned nothing from the tobacco industry? Oral administration eliminates the pulmonary health risks associated with inhalation of pyrolyzed products and allows for accurate dosing of active ingredients such as THC and CBD. Unfortunately, challenges are impeding market growth of oral products due to cannabinoids poor solubility and dispersibility rendering products with very low bioavailability. We intend to study the design of flowable powders containing cannabis oil. Addition of cannabis oils to powders such as maltodextrin (typically an excellent glassy carrier powder) lower its glass transition temperature causing the final powered to be sticky with poor flow performance, which will lead to a lack of consumer acceptance. We have designed a ternary phase diagram to study the flowability, dispersibility, and glass transition temperatures of maltodextrin-carrier oil-cannabis oil spray dried powders. The industry objective of this information is to allow Motif to design a shelf-stable maltodextrin cannabis-enriched ingredient potentially for the edible recreational market or that can be further processed and compacted into tables for the medical market (beyond the scope of this Engage).