Understanding formulation characteristics on the glass transition of spray powders fortified with cannabis oils

在加拿大，大麻目前被处方或在娱乐市场上作为干燥的植物材料或通过油和溶液口服，奇怪的是，作为个人性爱润滑剂(Fleure de Lune：HEXO Corp)。虽然大麻通常是吸烟的，但吸入燃烧的、干燥的植物物质显然与固有的健康风险有关，即使只有一小部分烟草也是不可接受的。难道我们没有从烟草行业学到任何东西吗？口服给药消除了与吸入热解产品相关的肺部健康风险，并允许准确地剂量有效成分，如THC和CBD。不幸的是，由于大麻类药物的溶解性和分散性差，以及生物利用度很低的呈现产品，挑战阻碍了口腔产品的市场增长。我们打算研究含有大麻油的可流动粉末的设计。在麦芽糊精(通常是一种很好的玻璃载体粉末)等粉末中添加大麻油会降低其玻璃化转变温度，导致最终粉末粘稠，流动性能较差，这将导致消费者无法接受。我们设计了一个三元相图来研究麦芽糊精载体油-大麻油喷雾干燥粉末的流动性、分散性和玻璃化转变温度。这一信息的行业目标是使Motif能够设计一种货架稳定的麦芽糊精大麻强化成分，可能用于可食用娱乐市场，或可进一步加工并压缩成医疗市场的表格(超出本项目的范围)。

In Canada, cannabis currently is prescribed or sold on the recreational market as dried plant material or orally administered via oils and solutions, and oddly as personal sex lubricant (Fleure de Lune: HEXO Corp). While cannabis is typically smoked, inhalation of burned, dry plant matter is obviously associated with inherent health risks which are unacceptable even if at a fraction of tobacco. Have we learned nothing from the tobacco industry? Oral administration eliminates the pulmonary health risks associated with inhalation of pyrolyzed products and allows for accurate dosing of active ingredients such as THC and CBD. Unfortunately, challenges are impeding market growth of oral products due to cannabinoids poor solubility and dispersibility rendering products with very low bioavailability. We intend to study the design of flowable powders containing cannabis oil. Addition of cannabis oils to powders such as maltodextrin (typically an excellent glassy carrier powder) lower its glass transition temperature causing the final powered to be sticky with poor flow performance, which will lead to a lack of consumer acceptance. We have designed a ternary phase diagram to study the flowability, dispersibility, and glass transition temperatures of maltodextrin-carrier oil-cannabis oil spray dried powders. The industry objective of this information is to allow Motif to design a shelf-stable maltodextrin cannabis-enriched ingredient potentially for the edible recreational market or that can be further processed and compacted into tables for the medical market (beyond the scope of this Engage).