Understanding formulation characteristics on the glass transition of spray powders fortified with cannabis oils

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In Canada, cannabis currently is prescribed or sold on the recreational market as dried plant material or orally administered via oils and solutions, and oddly as personal sex lubricant (Fleure de Lune: HEXO Corp). While cannabis is typically smoked, inhalation of burned, dry plant matter is obviously associated with inherent health risks which are unacceptable even if at a fraction of tobacco. Have we learned nothing from the tobacco industry? Oral administration eliminates the pulmonary health risks associated with inhalation of pyrolyzed products and allows for accurate dosing of active ingredients such as THC and CBD. Unfortunately, challenges are impeding market growth of oral products due to cannabinoids poor solubility and dispersibility rendering products with very low bioavailability. We intend to study the design of flowable powders containing cannabis oil. Addition of cannabis oils to powders such as maltodextrin (typically an excellent glassy carrier powder) lower its glass transition temperature causing the final powered to be sticky with poor flow performance, which will lead to a lack of consumer acceptance. We have designed a ternary phase diagram to study the flowability, dispersibility, and glass transition temperatures of maltodextrin-carrier oil-cannabis oil spray dried powders. The industry objective of this information is to allow Motif to design a shelf-stable maltodextrin cannabis-enriched ingredient potentially for the edible recreational market or that can be further processed and compacted into tables for the medical market (beyond the scope of this Engage).