Physiological mechanisms of dyspnea: role of neural respiratory drive

呼吸困难的生理机制：神经呼吸驱动的作用

• 批准号: RGPIN-2016-04918
• 负责人: Jensen, Dennis
• 金额: $ 2.04万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=682686
• 关键词: Physiological; mechanisms; dyspnea; role; neural

“Dyspnea” refers to the subjective awareness of breathing discomfort experienced by humans under conditions of physical stress such as exercise. In the general population and in patients with chronic cardiopulmonary disease, the symptom of dyspnea has emerged as a very strong indepenent predictor of disability and death. Indeed, approximately 10% of adults in the general population and up to 75% of adults with advanced chronic obstructive lung disease report experiencing dyspnea so severe that it impairs their ability to participate in regular physical activity. Despite the high burden and impact of dyspnea, the underlying cause(s) of this symptom remain poorly understood and largely understudied. Thus, the general aim of the proposed research program is to better understand the complex physiological mechanisms of dyspnea in human subjects by (1) assessing the effects of experimentally manipulating the drive to breathe on ratings of perceived dyspnea during exercise, (2) assessing the separate effects of inspiratory elastic and inspiratory resistive loading on the relationship between the drive to breathe and ratings of perceived dyspnea during exercise and (3) determining whether the origin of increased drive to breath influences the perception of dyspnea. Future therapies that lead to more effective relief of dyspnea in human subjects from health to chronic cardiopulmonary disease await a better understanding of the precise physiological mechanisms of this prevalent, complex and potentially disabling symptom, which will emerge as a result of this NSERC Discovery research program.**

“呼吸困难”是指人类在运动等身体应激条件下所感受到的呼吸不适的主观意识。在普通人群和慢性心肺疾病患者中，呼吸困难的症状已经成为残疾和死亡的一个非常强大的独立预测因子。事实上，在一般人群中，大约10%的成年人和高达75%的患有晚期慢性阻塞性肺病的成年人报告经历了严重的呼吸困难，以至于削弱了他们参与常规体力活动的能力。尽管呼吸困难的负担和影响很大，但这种症状的根本原因(S)仍然知之甚少，而且在很大程度上还没有得到充分的研究。因此，拟议的研究计划的总体目标是通过以下方式更好地了解受试者呼吸困难的复杂生理机制：(1)评估实验性地操纵呼吸动力对运动期间感觉到的呼吸困难的影响，(2)评估吸气弹性和吸气阻力负荷对运动中呼吸动力和感觉到的呼吸困难之间的关系的单独影响，以及(3)确定呼吸动力增加的来源是否影响对呼吸困难的感觉。未来的疗法将更有效地缓解人类从健康到慢性心肺疾病的呼吸困难，这需要更好地了解这种普遍、复杂和潜在的致残症状的确切生理机制，这种症状将作为NSERC发现研究计划的结果而出现。**