Contributions of lower extremity musculature to hip and knee joint coordination, stability, and regional tissue mechanics

下肢肌肉组织对髋关节和膝关节协调性、稳定性和区域组织力学的贡献

• 批准号: RGPIN-2019-05340
• 负责人: Burkhart, Timothy
• 金额: $ 2.33万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=684217
• 关键词: Contributions; lower; extremity; musculature; hip

The long-term goal of this program is to develop a research platform of engineering tools and computational models of the lower extremity to build a comprehensive understanding of joint mechanics ranging from the tissue to whole joint levels. The overall vision of this work is that it will produce valid information to improve lower extremity injury reduction, treatment and rehabilitation strategies resulting in reduced health care costs, improved patient satisfaction and more comfortable ageing of the general Canadian population. This will be addressed through the following objectives:******Objective 1) Quantify the individual muscle contributions to knee and hip joint stability in response to multi-planar and multi-joint tasks.***The purpose this objective is to determine the contributions of the lower extremity musculature to hip and knee joint kinematics and kinetics. This research will indicate the role of each of the lower extremity muscles in initiating different types of motion and stabilizing the joints.******Objective 2) Quantify regional stress and strain distributions in knee and hip joint soft tissue structures in response to active and passive loading protocols.***A custom designed micro-CT compatible joint motion simulator, developed in my lab, will be adapted so that it is capable of applying active muscle forces to cadaveric specimens. Using a CT imaging based method, regional ligament material properties can be calculated. The results of this research objective will describe the effect of muscle contributions on hip and knee joint ligament stresses and strains.******Objective 3 Development and validation of finite element models to measure joint contact mechanics. ***Image based finite element models will be developed and validated from CT scans taken in objective 2. Muscle tendons will be modelled as two-dimensional fiber reinforced membranes and non-linear spring elements while the ligaments will be modelled as non-linear springs. Following validation the contact mechanics within the joints will be quantified and compared across different loading conditions. The muscle-tendon forces from objective 1 will be input into the models to simulate active muscle loading******I anticipate that the completion of this work will result in the most comprehensive mapping of regional tissue mechanical properties to date and how these are affected by different types of physiological loading and the surrounding musculature. *****

该计划的长期目标是开发一个下肢工程工具和计算模型的研究平台，以建立从组织到整个关节水平的关节力学的全面理解。这项工作的总体设想是，它将产生有效的信息，以改善下肢损伤减少，治疗和康复战略，从而降低医疗保健成本，提高病人的满意度和更舒适的老龄化的一般加拿大人口。 这将通过以下目标来解决：** 目标1）量化个体肌肉对多平面和多关节任务中膝关节和髋关节稳定性的贡献。*目的是确定下肢肌肉组织对髋关节和膝关节运动学和动力学的贡献。这项研究将表明每个下肢肌肉在启动不同类型的运动和稳定关节中的作用。目的2）量化膝关节和髋关节软组织结构中响应主动和被动加载方案的局部应力和应变分布。*一个定制设计的微型CT兼容的关节运动模拟器，在我的实验室开发，将进行调整，使其能够施加积极的肌肉力量的尸体标本。使用基于CT成像的方法，可以计算局部韧带材料特性。本研究目标的结果将描述肌肉对髋关节和膝关节韧带应力和应变的影响。**目的3开发和验证有限元模型来测量关节接触力学。* 将根据目标2中拍摄的CT扫描开发并验证基于图像的有限元模型。肌腱将被建模为二维纤维增强膜和非线性弹簧元件，而韧带将被建模为非线性弹簧。确认后，将量化关节内的接触力学，并在不同载荷条件下进行比较。目标1中的肌肉-肌腱力将被输入到模型中，以模拟主动肌肉负荷 ** 我预计，这项工作的完成将导致迄今为止最全面的区域组织力学特性映射，以及这些特性如何受到不同类型的生理负荷和周围肌肉组织的影响。*****