Contributions of lower extremity musculature to hip and knee joint coordination, stability, and regional tissue mechanics

下肢肌肉组织对髋关节和膝关节协调性、稳定性和区域组织力学的贡献

• 批准号: RGPIN-2019-05340
• 负责人: Burkhart, Timothy
• 金额: $ 2.33万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=715499
• 关键词: Contributions; lower; extremity; musculature; hip

The long-term goal of this program is to develop a research platform of engineering tools and computational models of the lower extremity to build a comprehensive understanding of joint mechanics ranging from the tissue to whole joint levels. The overall vision of this work is that it will produce valid information to improve lower extremity injury reduction, treatment and rehabilitation strategies resulting in reduced health care costs, improved patient satisfaction and more comfortable ageing of the general Canadian population. This will be addressed through the following objectives: Objective 1) Quantify the individual muscle contributions to knee and hip joint stability in response to multi-planar and multi-joint tasks. The purpose this objective is to determine the contributions of the lower extremity musculature to hip and knee joint kinematics and kinetics. This research will indicate the role of each of the lower extremity muscles in initiating different types of motion and stabilizing the joints. Objective 2) Quantify regional stress and strain distributions in knee and hip joint soft tissue structures in response to active and passive loading protocols. A custom designed micro-CT compatible joint motion simulator, developed in my lab, will be adapted so that it is capable of applying active muscle forces to cadaveric specimens. Using a CT imaging based method, regional ligament material properties can be calculated. The results of this research objective will describe the effect of muscle contributions on hip and knee joint ligament stresses and strains. Objective 3 Development and validation of finite element models to measure joint contact mechanics. Image based finite element models will be developed and validated from CT scans taken in objective 2. Muscle tendons will be modelled as two-dimensional fiber reinforced membranes and non-linear spring elements while the ligaments will be modelled as non-linear springs. Following validation the contact mechanics within the joints will be quantified and compared across different loading conditions. The muscle-tendon forces from objective 1 will be input into the models to simulate active muscle loading I anticipate that the completion of this work will result in the most comprehensive mapping of regional tissue mechanical properties to date and how these are affected by different types of physiological loading and the surrounding musculature.

该项目的长期目标是开发一个工程工具和下肢计算模型的研究平台，以建立从组织到整个关节水平的关节力学的全面理解。这项工作的总体愿景是，它将产生有效的信息，以改善减少下肢损伤、治疗和康复战略，从而降低医疗保健费用，提高患者满意度，使加拿大一般人口更舒适地老龄化。这将通过以下目标来解决：