Mitochondrial dysfunction and vulnerability to oxidative stress in induced dopaminergic neurons (PD-iDANs) derived from sporadic Parkinson's disease patients

散发性帕金森病患者诱导多巴胺能神经元 (PD-iDAN) 的线粒体功能障碍和氧化应激脆弱性

• 批准号: 428940
• 负责人: Legault Emilie
• 金额: $ 1.27万
• 依托单位: Universit de Montral
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-12-01 至 2020-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=428940&lang=en
• 关键词: Aging; Alpha-Synuclein; Direct Reprogramming; Fibroblast; Induced Neurons; Mitochondria; Neurodegeneration; Oxidative Stress; Parkinson'S Disease; Pathophysiology

"The causes underlying over 90% of Parkinson's disease (PD) cases are unknown. This results in a lack of understanding of the mechanisms responsible for these non-familial forms of the disease, called idiopathic, preventing the development of cures or tre

“超过90%的帕金森病（PD）病例的原因是未知的。这导致对这些非家族性疾病（称为特发性）的机制缺乏了解，阻碍了治愈或治疗的发展。